The research interests of laboratory are to study host-pathogen interactions in microbial infection caused by bacteria, viruses, and fungi. Specifically, our focus has been on developing immunomodulation strategies targeting Toll-like receptor (TLR) signaling in preventing and/or treating infectious diseases affecting the eye (e.g. keratitis and endophthalmitis) and other organs. We use cutting-edge and high throughput “omics” technologies such as transcriptomics, lipidomics, and metabolomics combined with systems biology to study host immune responses to infection. Another area of our research is to understand mechanisms of antibiotic resistance among bacteria, prevalent in hospitals and the environment and develop alternative antimicrobial therapeutics to reduce antibiotic resistance.
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