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Phone
313-576-8302
Office Address
4100 John R St
HWCRC Room 624
Detroit, MI 48201
Department
Oncology
Laboratory Phone
313-576-8302
Laboratory Web Site
Research Description
One of the research goals of Dr. Benjamin Kidder's lab is to understand how stem cells pattern the epigenetic landscape in a way that facilitates distinct expression programs throughout development. Humans develop from a single fertilized egg into a complex organism with many cell types, each with its own distinct gene expression and epigenetic profile. These complex cellular states, when perturbed, can lead to diseases such as cancer. Our lab uses experimental, genomics, and computational biology tools to study the epigenetic regulation of stem cell and cancer function, genome stability, and reprogramming/transdifferentiation. We are particularly interested in understanding how epigenetic landscapes are regulated in cancer vs. normal cells, the role for heterochromatin in regulating genome stability, and how histone modifying enzymes contribute to the diverse cellular repertoire that exists in mammals.
Recent Publications
Allison V Mitchell, Ling Wu, C James Block, Mu Zhang, Justin Hackett, Douglas B Craig, Wei Chen, Yongzhong Zhao, Bin Zhang, Yongjun Dang, Xiaohong Zhang, Shengping Zhang, Chuangui Wang, Heather Gibson, Lori A Pile, Benjamin Kidder, Larry Matherly, Zhe Yang, Yali Dou, Guojun Wu. FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis. Nature Communications 2022;13:6548.
He R, Xhabija B, Gopi LK, Kurup JT, Xu Z, Liu Z, Kidder BL. H3K4 demethylase KDM5B regulates cancer cell identity and epigenetic plasticity. Oncogene. 2022;41:2958-72.
Gopi LK, Kidder BL. Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains. Nature Communications. 2021;12:1419.
Kurup JT, Kidder BL. H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells. Development. 2020;147:188516.
KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer. Xhabija B, Kidder BL. Semin Cancer Biol. 2019;57:79-85.
Contribution of H3K4 demethylase KDM5B to nucleosome organization in embryonic stem cells revealed by micrococcal nuclease sequencing. Kurup JT, Campeanu IJ, Kidder BL. Epigenetics Chromatin. 2019;12:20.
Kurup JT, Kidder BL. Identification of H4K20me3 and H3K4me3-associated RNAs using CARIP-Seq expands the transcriptional and epigenetic networks of embryonic stem cells. J Biol Chem. 2018 Aug 16. pii: jbc.RA118.004974. [Epub ahead of print].
He R, Kidder BL. Culture of haploid blastocysts in FGF4 favors the derivation of epiblast stem cells with a primed epigenetic and transcriptional landscape. Sci Rep. 2018;8:10775.
Xu J, Kidder BL. H4K20me3 co-localizes with activating histone modifications at transcriptionally dynamic regions in embryonic stem cells. BMC Genomics. 2018;19:514.
Kidder BL. CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells. J Vis Exp. 2018;29889205.
Xu J, Kidder BL. KDM5B decommissions the H3K4 methylation landscape of self-renewal genes during trophoblast stem cell differentiation. Biol Open. 2018;7:bio031245.
Vizcardo R, Klemen ND, Islam SMR, Gurusamy D, Tamaoki N, Yamada D, Koseki H, Kidder BL, Yu Z, Jia L, Henning AN, Good ML, Bosch-Marce M, Maeda T, Liu C, Abdullaev Z, Pack S, Palmer DC, Stroncek DF, Ito F, Flomerfelt FA, Kruhlak MJ, Restifo NP. Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System. Cell Rep. 2018;22:3175-90.
Education/Training
B.A. in Chemistry and Biology (2001): Saint Olaf College, Northfield, MN
Ph.D. in Molecular, Cellular, Developmental Biology and Genetics (2007): University of Minnesota, Minneapolis, MN
Postdoctoral Fellow: EMD/Merck Serono Research Institute, Rockland, MA
Principal Investigator: EMD/Merck Serono Research Institute, Rockland, MA
Research Fellow in Epigenome Biology: National Heart, Lung and Blood Institute (NHLBI, NIH), Bethesda, MD
Research Description
• Stem Cells
• Genomics
• Transcriptional Networks