Description
Currently, exogenous insulin therapy is used to manage blood glucose levels in patients with diabetes. Phenolic preservatives (PP) are used in insulin formulations to stabilize insulin, but PP are cytotoxic, inducing inflammation and fibrosis at infusion sites. We are employing novel transgenic mouse models (Cre/loxP) to investigate the contributions of leukocytes related to PP and the foreign body (e.g. infusion catheter) in limiting effective insulin therapy.
Qualifications
Work effectively in a team; good computer and communication skills; able to work with rodents; tissue culture experience
Duties
Assistance in breeding, maintaining and genotyping mouse lines, collection of blood samples including performing basic assays for circulating metabolites. Assistance in taking images.
Last Updated
May 13, 2021