Diane Cress

projects

Faculty Profile

Associate Professor
af2429@wayne.edu

Department

Nutrition and Food Science

Phone

313-577-5978

Fax

313-577-8616

Office

2022 Science Hall Office
2016 Science Hall Lab

Biography

 

I am a Registered Dietitian, and hold a PhD in Nutrition and Food Science. I have worked as a clinical dietitian, as an educator, and as a researcher over the many years of my career. I joined the Department of Nutrition and Food Science at Wayne State University as an Assistant Professor in 2008. For nearly 20 years, my research program investigated the impact of endogenous DNA damage on aging. During these years we studied the impact of nutrition on DNA stability. Currently, I am working to further elucidate the  impact of nutrition on population health and disease prevention. The distribution of resources in our food systems impact both hunger and climate. Reducing food waste and shifting dietary patterns are key actionable measures impacting hunger and climate that are of interest to me.

As a professor, I teach both in the classroom and in the community.  In the classroom, I teach an upper level course covering the biochemistry of vitamins and minerals. Outside the classroom I create opportunities for students to work in the food community in Detroit. My goal is to get students engaged in these issues in hopes of growing a generation of young people excited about this work.

If you are a student interested in internships or other volunteer opportunities, please visit https://s.wayne.edu/cress/

Selected Publications

1. Cabelof, D.C. (1994). Preventing infection from foodborne pathogens in liver transplant patients. J. American Dietetic Association, 94(10): 1140-4. (4.021/5)
2. Cabelof D.C., Raffoul J.J., Yanamadala S., Ganir C., Guo Z., Heydari, A.R. (2002). Attenuation in DNA polymerase -dependent base excision repair pathway and increased DMS induced mutagenicity in aged mice. Mutation Research, 500:135-145. (2.398/102)
3. Cabelof D.C., Raffoul J.J., Yanamadala S., Guo Z., Heydari, A.R. (2002). Role of DNA polymerase -dependent base excision repair in response to 2-nitropropane. Carcinogenesis, 23:1419-1425. (5.072/93)
4. Cabelof D.C., Yanamadala S., Raffoul J.J., Soofi A.S., Guo Z., Heydari, A.R. (2003). Caloric restriction promotes genetic stability by induction of base excision repair and reversal of its age-related decline. DNA Repair 2:295-307. (4.461/115)
5. Cabelof D.C., Guo Z. Raffoul J.J., Sobol R.W., Wilson, S.H., Richardson, A., Heydari, A.R. (2003). Base excision repair deficiency caused by polymerase β haploinsufficiency: Accelerated DNA damage and increased mutational response to carcinogens. Cancer Research, 63: 5799-5807. (9.130/110)
6. Raffoul J.J., Cabelof D.C., Nakamura J., Meira L.B., Friedberg E.C., Heydari, A.R. (2004). Apurinic/apyrimidinic endonuclease (APE/ref-1) haploinsufficient mice display tissue-specific differences in DNA polymerase β-dependent base excision repair. J. Biol. Chem, 279:18425-18433. (4.010/46)
7. Cabelof, D.C., Raffoul, J.J., Nakamura, J., Kapoor, D., Abdalla, H., Heydari, A.R. (2004) Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency. J Biol Chem, 279:36504-36513. (4.010/44)
8. Liu, M., Ge, Y., Cabelof, D.C., Aboukameel, A., Heydari, A.R., Mohammad, R., Matherly, L.H. (2005): Structure and regulation of the murine reduced folate carrier gene: identification of 4 non-coding exons and promoters and regulation by dietary folates, J. Biol. Chem. 280: 5588-5597. (4.010/61)
9. Cabelof, D.C., Nakamura J., Heydari, A.R. (2006) Development of a sensitive biochemical assay for the detection of uracil in DNA. Environmental and Molecular Mutagenesis, 47:31-7. (3.254/14)
10. Cabelof, D.C., Raffoul, J.J., Ge, Y., Van Remmen, H., Matherly, L.H., Heydari, A.R. (2006). Age-related loss of the DNA repair response following exposure to oxidative stress. J Gerontology, A Biol Sci. Med. Sci. 61:427-434. (4.902/56)
11. Cabelof, D.C., Ikeno, Y., Nyska, A., Busuttil, R.A., Anyanagwe, N., Vijg, J., Matherly, L.H., Tucker, J.D., Wilson, S.H., Richardson, A., Heydari, A.R. (2006) Haploinsufficiency in DNA polymerase β increases cancer risk with age and alters mortality rate. Cancer Research 66:7460-7465. (9.130/77)
12. Kanellis, P., Gagliardi, M., Banath, J.P., Szilard, R.K., Nakada, S., Galicia, S., Sweeney, F.D., Cabelof, D.C., Olive, P.L., Durocher, D. (2007) A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. PLoS Genet 3: 1438-1453. (5.54/52)
13. Cabelof, D.C. (2007) Aging and base excision repair: In need of a comprehensive approach. DNA Repair (Amst). 6:1399-402. (4.461/7)
14. Qui, A., Min, S., Jansen, M., Malhotra, U., Tsai, E., Cabelof, D.C., Matherly, L.H., Zhao, R., Akabas, M.H., Goldman, I.D. (2007) Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, response to dietary folate restriction. Am J Physiol Cell Physio 293:1669-78. (3.454/116)
15. Unnikrishnan, A., Raffoul, J.J., Patel, H.V., Prychitko, T.M., Anyangwe, N., Meira, L.B., Friedberg, E.C., Cabelof, D.C., Heydari, A.R. (2009) Oxidative stress alters base excision repair pathway and increases apoptotic response in Apurinin/apyrimidinic endonuclease 1/Redox factor-1 haploinsufficient mice. Free Rad Biol Med 46:1488-99. (6.02/50)
16. Cabelof DC, Chen Q, Ge Y, van Remmen H, Matherly LH, and Taub JW (2009) Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome. Blood 114:2753-63. (15.132/62)
17. Simon K, Dewundara S, van Remmen H, Dombkowski AA, and Cabelof DC (2009) Transcriptional profiling of the age-related response to genotoxic stress points o differential DNA damage response with age. Mech Ageing Dev 130: 637-47. (3.748/9)
18. Lucente LV, Unnikrishnan A, Pilling AB, Patel HV, Kushwaha D, Dombkowski A, Schmelz EM, Cabelof DC, Heydari AR (2010). Folate deficiency provides protection against colon carcinogenesis in DNA polymerase β haploinsufficient mice. J Biol Chem. 285:19246-58.(4.010/24)
19. Unnikrishnan KA, Prychitko TM, Patel HV, Chowdhury ME, Pilling AB, Ventrella-Lucente LF, Papakonstantionu EV, Cabelof DC, and Heydari AR (2011) Folate deficiency regulates expression of DNA polymerase β in response to oxidative stress. Free Radic Biol Med 50:270-80. (6.02/21)
20. Cabelof DC (2012) Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance. Cell Mol Life Sci 69:727-40. (6.721/19)
21. Simon KW, Ma H, Dombkowski AA and Cabelof DC (2012) Aging alters folate homeostasis and DNA damage response in colon. Mech Ageing Dev 133:75-82. (3.748/5)
22. Patterson D and Cabelof DC (2012) Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging. Mech Ageing Dev 133:133-7. (3.748/39)
23. Rosati R, Ma H and Cabelof DC (2012) Folate and colorectal cancer in rodents: a model of DNA repair deficiency, J Oncology 105949.(4.528/6)
24. Ahmed AA, Smoczer C, Pace B, Patterson D and Cress (Cabelof) D (2018) Loss of DNA polymeraseβ induces senescence, Environmental and Molecular Mutagenesis 59:603-12. (3.254/0)
25. Beydoun S, Fardous AM, Saruna MM, Beydoun AG, Sorge JA, Ma H, Aoun G, Unnikrishnan A, Cabelof DC, Heydari AR (2021) Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism, Exp Gerontol 150: 111387 https://doi.org/10.1016/j.exger.2021.111387
26. Fardous AM, Beydoun S, James AA, Ma H, Cabelof DC, Unnikrishnan A, Heydari AR (2021) The timing and duration of folate restriction differentially impacts colon carcinogenesis, Nutrients 14: 16 https://doi.org/10.3390/nu14010016.
27. Alnabbat, K, Fardous, A, Cabelof DC, Heydari AR (2022) Excessive folic acid induces a functional folate deficiency in Human lymphocytes. Curr. Issues Mol. Biol. 44: 1452-1462. https://doi.org/10.3390/cimb44040097.


 

 

Courses taught

  • NFS 6850 Controversial Issues in Nutrition, 2 credits, Fall 2016, Fall 2015, Fall 2014
  • NFS 6860 Controversial Issues in Nutrition (Clinical), 2 credits,Winter 2016, Winter 2015, Winter 2014
  • NFS 4231 Human Nutrition: Micronutrients, 3 credits, Winter 2017, Winter 2016, Winter 2015
  • NFS 7230 Nutrition and Physical Performance, 3 credits, Fall 2016, Fall 2015
  • NFS 7250 Nutrition and Aging, 3 credits, Fall 2013

Other qualifications directly relevant to courses taught

 Registered Dietitian (RD), Academy of Nutrition and Dietetics (since 1990)

Research Description

For the past 15 years I have been studying the role of DNA repair in maintaining genome stability, with a particular focus on the impact of aging on these processes. We have also studied the impact of dietary components on genome stability. Most recently we have been evaluating the role that suboptimal DNA repair may play in the accelerated aging seen in individuals with Down syndrome. This work will be carried on by those I have trained and those I have worked with. Contact me if you would like more information on how to get involved in this work.  

Affiliated Departments