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Office Address
3303 Scott Hall
Assistant
Suzanne Shaw | 313-577-5323
Administrator
Lamar Glass | 313-577-0712
Biography
Dr. Grossman is the Henry L. Brasza Professor of Molecular Medicine and Genetics and Director of the Center for Molecular Medicine and Genetics; he is also Professor of Internal Medicine. He received the B.S. degree in chemistry from the City College of New York and the Ph.D. degree in genetics and biochemistry from the Albert Einstein College of Medicine, where he studied the replication and structure of yeast mitochondrial DNA with Julius Marmur. He then carried out postdoctoral research at the California Institute of Technology, working with Jerome Vinograd on mammalian mitochondrial DNA, where he was named a Fellow of the Jane Coffin Childs Memorial Fund for Medical Research. He has been a member of the Wayne State University community for more than 25 years. He serves on the editorial boards of Mitochondrion and Cells and was previously Contributing Editor for Science. He is Treasurer of the American Electrophoresis Society and serves on the Research Policy Review Committee of the United Mitochondrial Disease Foundation. The Grossman lab works on mitochondrial genetics and function with an emphasis on dysregulation in disease and, most recently, pharmacological restoration of normal phenotype.
Research Description
Our laboratory first isolated and characterized the genes for a number of COX subunits, recently concentrating on the lung-expressed subunit 4 isoform gene, COX4i2. This work has led to the exciting discovery that CHCHD2 (MNRR1), a regulator of COX4i2, is also a major stress-responsive regulator of mitochondrial function.
Dr. Grossman is an editor of Mitochondrion, and was previously on the editorial board of Biochemica Biophysica Acta and was a contributing editor for Science.