Lawrence Grossman


Faculty Profile

Director (Academic)

Office Address

3129 Scott Hall, 540 E. Canfield, Detroit, MI 48201

Education Training

B.S.: The City College of New York 

Ph.D.: Albert Einstein College of Medicine (Genetics and Biochemistry), New York, New York

Postdoctoral: California Institute of Technology, Pasadena, CA

Laboratory Web Site



Research Description

The Grossman laboratory studies the function and regulation of mitochondrial genes with a focus on cytochrome c oxidase (COX) and its regulators. COX is the terminal of the four complexes and catalyzes the transfer of electrons from cytochrome c to oxygen. COX is composed of 13 subunits: the 3 largest are coded by mitochondrial DNA, the others by nuclear DNA.

Our laboratory first isolated and characterized the genes for a number of COX subunits, recently concentrating on the lung-expressed subunit 4 isoform gene, COX4i2. This work has led to the exciting discovery that CHCHD2 (MNRR1), a regulator of COX4i2, is also a major stress-responsive regulator of mitochondrial function.

Dr. Grossman is an editor of Mitochondrion, and was previously on the editorial board of Biochemica Biophysica Acta and was a contributing editor for Science.

Affiliated Departments