Faculty Profile

Assistant Professor
hm2608@wayne.edu

Phone

(313) 576-9967

Department

Oncology

Laboratory Web Site

https://imaginglab.org/

Research Description

My lab is evaluating new probes and strategies for combining radioligand and optoacoustic tools to study cancers. My main focus is to selectively label malignant growths in vivo to allow for their detection, treatment, and removal. Our goal is to be able to map out and observe imaging/therapeutic response via optoacoustics, which will ultimately benefit patients for early detection of cancer and non-invasive monitoring.

Recent Publications

C. Huang, N.R. Filippone, T. Reiner, S. Roberts*, Sensors and Inhibitors for the Detection of Ataxia Telangiectasia Mutated (ATM) Protein Kinase. Mol. Pharmaceutics 2021;18:2470-81.

S. Roberts, E. Khera, C. Choi, T. Navaratna, J. Grimm, GM. Thurber, and T. Reiner*. Optoacoustic imaging of GLP-1 Receptor with a near-infrared exendin-4 analog. J. Nucl. Med. 2021;62:10.

PMR. Pereira‡, S. Roberts‡, F. Figueira, JPC. Tome, T. Reiner, JS. Lewis*, PET/CT imaging with a 18 F- labeled galactodendritic unit in a galectin-1 overexpressing orthotopic bladder cancer model. J. Nucl. Med. 2020;61:1369-75.

HM. Schöder, PDS. França, R. Nakajima, EM Burnazi, S. Roberts, C. Brand, M. Grkovski, A. Mauguen, MPS Dunphy, R. Ghossein, SK Lyashchenko, JS Lewis, JA O'Donoghue, I. Ganly, SG. Patel, LY Nancy, T. Reiner*, Safety and feasibility of PARP1/2 imaging with 18F-PARPi in patients with head and neck cancer. Clinical Cancer Research 2020;26:3110-6.

K. Haedicke, L. Agemy, M. Omar, A. Berezhnoi, S. Roberts, C. Longo-Machado, M. Skubal, K. Nagar, H. Hsu, K. Kim, T. Reiner, J. Coleman, V. Ntziachristos, A. Scherz, J. Grimm*. High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies. Nature Biomedical Engineering 2020;4:286-97.

S. Roberts, A. Strom, C. Choi, C. Andreou, S. Kossatz, C. Brand, T. Williams, M. Bradbury, MF. Kircher, YK. Reshetnyak, J. Grimm, JS. Lewis, T. Reiner*, Acid specific dark quencher QC1 pHLIP for multi- spectral optoacoustic diagnoses of breast cancer. Scientific Reports 2019;9:8550.

G. Pirovano, S. Roberts, T. Reiner*, TOPKi-NBD: a fluorescent small molecule for tumor imaging. Eur J Nucl Med Mol Imaging 2019;47:1003-10.

S. Roberts, C. Andreou, C. Choi, P. DonabedianY, M. Jayaraman1, EC Pratt, J. Tang, C. Pérez-Medina, MJ. Cruz, WJM Mulder, J. Grimm, M. Kircher, T. Reiner*, Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer. Chem. Sci., 2018;9:5646-57.

S. Roberts, M. Seeger, Y. Jiang, A. Mishra, F. Sigmund, A. Stelzl, A. Lauri, P. Symvoulidis, H. Rolbieski, M. Preller, XL Deán-Ben, D. Razansky, T. Orschmann, SC Desbordes, P. Vetschera, T. Bach, V. Ntziachristos, G.G Westmeyer*. Calcium Sensor for Photoacoustic Imaging. J. Am. Chem. Soc. 2018;140:2718-21.

Education/Training