| Faculty Profile |
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Department
Chemistry
Phone
313-577-9823
Fax
313-577-8822
Office
Chem 373
Selected publications
Reviews and other summaries
(Underlined are undergraduate student contributions.)
13) Trimpin, S.,* Novel Ionization Processes for Use in Mass Spectrometry: ‘Squeezing’ Nonvolatile Analyte Ions from Crystals and Droplets. Rapid Commun. Mass Spectrom. 33(SI): 96–120, 2019. (Special Issue Highlighting Associate Editors)
This paper was selected to be highlighted on the cover page of the journal
12) Trimpin, S.,* Karki, S., Marshall, D.D., Inutan, E.D., Meher, A.K., Madarshahian, S., Fenner, M.A., McEwen, C.N.,* Novel and Traditional Ionization Methods for Mass Spectrometry Combined to Provide More Comprehensive Analyses. LCGC North America, 2018, March issue, 35(8), 507–510.
11) Trimpin, S.,* Redefining Simplicity in Ionization: Discovery and Implementation of Novel Ionization Processes in Mass Spectrometry. LCGC North America 35(8): 507–510, 2017.
10) Peacock, P.M., Zhang, W.J., Trimpin, S.,* Advances in Ionization for Mass Spectrometry, Anal. Chem. 89(1): 372−388, 2017. (invited contribution to the 2017 Special)
9) Trimpin, S.,* Analytical Scientist highlighted In My View (an invited opinion article on MS Technology), 2016, September issue, pages 18–19.
8) Trimpin, S.,* Thawoos, S., Lu, I-C., DeLeeuw, J.L., Hoang, K., Devereaux, Z.J., Pophristic, M., Chakrabarty, S., Caruso, J.A., Stemmer, P.M., Narayan, S.B., McEwen, C.N., Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drug and Clinical Analyses. LCGC and Spectroscopy, 2016, May issue, pages 8–19.
7) Trimpin, S.,* Wang, B., Lutomski, C.A., El-Baba, T.J., Harless, B.M., A Convenient Alternative to MALDI and ESI, by request of the journal republished in ‘Current Trends in Mass Spectrometry’ (www. spectroscopyonline.com), LCGC and Spectroscopy 31(3): 53–61, 2016.
6) Trimpin, S.* “Magic” Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom. 27(1): 4–21, 2016. (invited Critical Insight Article dedicated for controversial topics and established experts in the field)
5) Trimpin, S.,* Chakrabarty, S., Wang, B., Hoang, K., Lutomski, C.A., Inutan, E.D., McEwen, C.N., Non-Conventional Alternatives to LC/MS, LCGC and Spectroscopy, 2015, May issue, pages 22–33.
4) Trimpin, S.,* Wang, B., Lutomski, C.A., El-Baba, T.J, Harless, B.M., A Convenient Alternative to MALDI and ESI, in ‘Current Trends in Mass Spectrometry’ (www. spectroscopyonline.com), LCGC and Spectroscopy, 2014, May issue, pages 8–17.
3) El-Baba, T.J, Lutomski, C.A., Wang, B., Inutan, E.D., Trimpin, S.,* Toward High Spatial Resolution Sampling and Characterization of Biological Tissue Surfaces using Mass Spectrometry. Anal. Bioanal. Chem. 406(17):4053–4061, 2014. (Review)
2) Trimpin, S.,* Wang, B., Lietz, C.B., Marshall, D.D., Richards, A.L., Inutan, E.D., New Ionization Processes and Applications for Use in Mass Spectrometry. Crit. Rev. Biochem. Mol. Biol. 48(5):409–429, 2013. (Review)
1) Trimpin, S.,* A Perspective on MALDI Alternatives - Total Solvent-free Analysis and Electron Transfer Dissociation of Highly Charged Ions by Laserspray Ionization. J. Mass Spectrom. 45(5): 471–485, 2010. (Special Feature)
This paper was highlighted on the cover page of the journal.
Recent peer-reviewed papers
(Underlined are undergraduate student contributions.)
8) Cao, Y., Lee, C., Davis, E.T.J., Si, W., Wang, F.,* Trimpin, S.,* Luo, L.,* 1000-Fold Preconcentration of Per- and Polyfluorinated Alkyl Substances (PFAS) within 10 min via Electrochemical Aerosol Formation. Anal. Chem. 91(22): 14352-14358, 2019.
This paper was selected to be highlighted on the cover page of the journal
7) Skjærvø, Ø., Trimpin, S., Halvorsen, T.G.,* Matrix Assisted Ionization Mass Spectrometry in Targeted Protein Analysis – An Initial Evaluation. Rapid Commun. Mass Spectrom. 2019, DOI: 10.1002/rcm.8437. (Special Issue on ‘New Ionization Processes in Mass Spectrometry’)
6) Karki, S., Meher, A.K., Inutan, E.D., Pophristic, M., Marshall, D.D., Rackers, K., Trimpin, S.,* McEwen, C.N.,* Development of a Robotics Platform for Automated Multi-ionization Methods for Mass Spectrometry. Rapid Commun. Mass Spectrom. 2019, DOI: 10.1002/rcm.8449. (Special Issue on ‘New Ionization Processes in Mass Spectrometry’)
5) Lee, C., Inutan, E.D., Chen, J.L., Mukeku, M.M., Weidner, S.M., Trimpin, S., Ni, C.K.,* Toward Understanding the Ionization Mechanism of Matrix‐Assisted Ionization using Mass Spectrometry Experiment and Theory. Rapid Commun. Mass Spectrom. 2019. DOI: 10.1002/rcm.8382 (Special Issue on ‘New Ionization Processes in Mass Spectrometry’)
4) Trimpin, S.,* Inutan, E.D., Karki, S., Elia, E.A., Zhang, W.J., Weidner, S.M., Marshall, D.D., Hoang, K., Lee, C., Davis, E.T.J., Smith, V., Meher, A.K., Cornejo, M., Auner, G.W., McEwen, C.N., Fundamental Studies of New Ionization Technologies and Insights from IMS-MS. J. Am. Soc. Mass Spectrom. 2019, 30, 1133–1147. (Invited contribution to special issue on ‘ion mobility’ in honor of von Helden, Jarrold, Clemmer ASMS Distinguished Contribution Award)
3) Trimpin, S.,* Pophristic, M.,* Adeniji'Adele, A., Tomsho, J.W., McEwen, C.N.,* Vacuum Matrix-Assisted Ionization Source Offering Simplicity, Sensitivity, and Exceptional Robustness in Mass Spectrometry. Anal. Chem. 90(19): 11188-11192, 2018.
2) Trimpin, S.,* Lee, C., Weidner, S.M., El-Baba, T. J., Lutomski, C.A., Inutan, E.D., Foley, C.D., Ni, C.K., McEwen, C.N., Unprecedented Ionization Processes in Mass Spectrometry Provide Missing Link between ESI and MALDI. ChemPhysChem 19(5): 581–589, 2018.
This paper was selected to be highlighted on the cover page of the journal
1) Trimpin, S.,* Lu, I-C., Rauschenbach, S., Hoang, K., Wang, B., Chubatyi, N.D., Zhang, W.-J., Inutan, E.D., Pophristic, M., Sidorenko, A., McEwen, C.N., Spontaneous Charge Separation and Sublimation Processes are Ubiquitous in Nature and in Ionization Processes in Mass Spectrometry. J. Am. Soc. Mass Spectrom. 29(2): 304–315, 2018. (Invited contribution to special issue on Asilomar Conference)
Research Description
The inventors of electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) MS shared a portion of the 2002 Nobel Prize in Chemistry because of the importance of these ionization methods in advancing science. In spite of the importance, the ionization mechanisms of these methods are not yet fully understood. We have discovered an ionization process that uses a matrix, similar to MALDI, but produces ions having charge states nearly identical to ESI. This novel ionization process is initiated by heat or vacuum, and does not require either voltage or a laser used in ESI and MALDI, respectively. Understanding how ESI-like mass spectra can be obtained from a solid surface in vacuum without laser ablation, or applied heat or voltage, and using a matrix compound that has no acidic hydrogen atoms, is of broad scientific interest and has the potential to unlock the mysteries surrounding ionization processes capable of ionizing nonvolatile compounds.
The theme to our current research is to study fundamentals of a newly discovered method for transferring molecules, regardless of size or volatility, from the solid state in a small molecule matrix to gas-phase ions for analysis by MS. The method only requires exposure of the sample in matrix to the vacuum inherent with all mass spectrometers. The ability to transport molecules at least as large as bovine serum albumin (67 kDa) into the gas phase as highly protonated ions without input of external energy is unprecedented in science, analytically important, and of fundamental interest in understanding ionization processes. Knowledge of the fundamentals of how this process occurs will advance our scientific understanding for all ionization methods whereby nonvolatile molecules are converted from the solid or liquid states to gas-phase ions, and provide guidance on how to increase the efficiency of ionization. Using the same analyte solutions and instrumentation designed for ESI or MALDI MS, under similar conditions, the newest ionization method, termed matrix assisted ionization vacuum, is already at least as sensitive as ESI or intermediate pressure MALDI, and offers the ability to rapidly interrogate specific surface features by simply applying a matrix solution to the surface defect and exposure to the vacuum at the atmospheric pressure inlet of the mass spectrometer. Improved ionization will ultimately minimize the surface area that can be interrogated, possibly reaching single cell analyses in the future. The simplicity of the new ionization method is particularly advantageous, and holds promise for novel applications for which currently trained personnel are needed.
Application Areas of the Unprecedented Ionization Processes Developed into Powerful Technologies and Methods
Medical, clinical, doctors offices, personalized medicine
Environmental exposure, forensics, food safety
Safe, innovative, tailored materials
Effective drugs, pharmaceuticals