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Office Address
Louis M. Elliman Clinical Research Building
421 E. Canfield, Rm: 2146
Detroit, MI 48201
Biography
Dr. Li Li received her BS degree from University of Science and Technology of China in 1985; she went on to obtain a Ph.D in Molecular Biology and Biochemistry from University of Texas at Houston in 1991. In 1996, she joined the faculty at Wayne State University as an assistant professor.
Current Academic and Professional Appointments
- Professor, Department of Internal Medicine & Center for Molecular Medicine and Genetics, Wayne State University
Professional Organization Memberships/Involvements
- American Heart Association
- Chinese American Heart Association
- North American Vascular Biology Organization
- The American Physiological Society
- National Marfan Foundation
Research Description
The research program in Dr. Li Li’s laboratory is centered on molecular mechanisms of the pathogenesis of cardiovascular diseases including aortic aneurysms, Marfan syndrome and atherosclerosis. The ultimate goal of our research is to discover biomarkers for the diagnosis and treatment of aneurysm dissection and rupture. We recently generated a new mouse aneurysm rupture model that contains a FBN1 mutation found in Marfan patients. Our current research focus on the discovery of key signal pathways in regulating transcription regulatory network in response to FBN1 mutation and metabolic stress. We are particularly interested in molecular mechanisms of defective ECM-cytoskeleton interaction in inflammation, oxidative stress and osteochondrogenesis during the pathogenesis of vascular diseases using tissue culture and mouse aneurysm models.