projects

Supramolecular organization and regulation of metabolic enzymes (ongoing)
Role of organelle contact sites in nutrient signaling and metabolic regulation (ongoing)

Faculty Profile

Assistant Professor
hg7223@wayne.edu

Biological Sciences Building, Room 4107, 5177

Vladimir Girik, Suihan Feng, Hanaa Hariri, W Mike Henne, Howard Riezman (2022). Vacuole-specific lipid release for tracking intracellular lipid metabolism and transport in Saccharomyces cerevisiae. ACS Chem. Biol. 2022, 17, 6, 1485–1494
Hanaa Hariri, Mike Henne (2022). Filling in the gaps: SNX-RGS proteins as multi-organelle tethers. Journal of Cell Biology. DOI: 10.1083/jcb.202203061
Blessy Paul, Saroja Weeratunga, Vikas A. Tillu, Hanaa Hariri, W. Mike Henne and Brett M. Collins (2022). Structural Predictions of the SNX-RGS Proteins Suggest They Belong to a New Class of Lipid Transfer Proteins. Front. Cell Dev. Biol., https://doi.org/10.3389/fcell.2022.826688

Mike F. Renne, Hanaa Hariri* (2021). Fatty Acid Channeling, Trafficking, and Metabolism at Lipid Droplet Contact Sites. Frontiers in Cell Dev. Biol. doi: 10.3389/fcell.2021.726261. *Corresponding author
Lluc Mosteiro, Hanaa Hariri, Jelle van den Ameele (2021). Metabolic decisions in development and disease. Development. Meeting Review. Vol. 148 Issue 11
Sean Rogers, Hanaa Hariri, Long Gui, N. Ezgi Wood, Natalie Speer, Daniela Nicastro, W. Mike Henne (2021). Glucose restriction drives spatial reorganization of mevalonate metabolism. Elife. 10:e62591 DOI: 10.7554/eLife.62591

Hanaa Hariri (2020). Topography and Functions of Membrane Contact Sites. Encyclopedia of Biological Chemistry 3rd Edition
N Ezgi Wood, Piya Kositangool, Hanaa Hariri, Ashley Marchand, Mike Henne (2020). Nutrient signaling, stress response, and interorganelle communication are non-canonical determinants of cell fate. Cell Reports. Vol 33, Issue 9
Sanchari Datta, Jade Bowerman, Hanaa Hariri, Rupali Ugrankar, KaitlynM. Eckert, Chase Corley, Gonçalo Vale, Jeffrey G. McDonald, Mike Henne (2020). Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease. Proceedings of the National Academy of Sciences 117 (52) 33282-33294
Mike Henne, Joel Goodman, Hanaa Hariri* (2020). Spatial compartmentalization of lipid droplet biogenesis. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1865, 158499. *Corresponding author

Rupali Ugrankar, Jade Bowerman, Hanaa Hariri, Sanchari Datta, Sonia Gonzalez, Joseph Gonzalez, and W. Mike Henne (2019). Drosophila Snazarus regulates a lipid droplet sub-population at plasma membrane-droplet contacts in fat body adipocytes. Developmental Cell. 50: 557–572
Hanaa Hariri, Natalie Speer, Jade Bowerman, Sanchari Datta, Sean Rogers, Ryan Feathers, Rupali Ugrankar, W. Mike Henne (2019). Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating fatty acid processing and lipid droplet biogenesis. Journal of Cell Biology. 218:1319-1334
Sanchari Datta, Yang Liu, Hanaa Hariri, W. Mike Henne (2019). Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts. Journal of Cell Biology. 218:1335-1351

Hanaa Hariri, Sean Rogers, Rupali Ugrankar, Yang Lydia Liu, J. Ryan Feathers, W. Mike Henne (2018). Lipid droplet biogenesis is spatially coordinated at yeast ER-lysosome contact sites in response to nutritional stress. EMBO Reports. 19: 57–72
Dale Bryant, Yang Liu, Sanchari Datta, Hanaa Hariri, Glenn Anderson, Emma Peskett, Charalambos Demetriou, Marian Seda, Dagan Jenkins, Sergio Sousa, Peter Clayton, Maria Bitner-Glindzicz, Gudrun Moore, Mike Henne, Philip Stanier (2018). SNX14 mutations affect cholesterol metabolism at the endoplasmic reticulum in SCAR20. Human Molecular Genetics. 27:1927–1940
Hanaa Hariri, Rupali Ugrankar, Yang Liu, and W. Mike Henne (2018). Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution. Communicative and Integrative Biology. Review. 9(3):e1156278

The Hariri Lab officially opens in January 2021, and we are looking for scientists to join our team!

Hanaa Hariri