Zhengping Yi

Suffix

Ph.D.

Office Location

Integrative Biosciences Center, Room 2405; EACPHS, Room 3146

Phone

313-577-0823

Department

Pharmaceutical Sciences

Degrees and Certifications

• 2004-2004: Postdoctoral research associate, University of Texas Health Science Center at San Antonio; Field of study: Proteomics & Diabetes
• 2000-2004: Postdoctoral research associate, Purdue University; Field of study: Protein Biochemistry
• 1997-2000: Ph.D., Nanjing University; Field of study: Supramolecular Chemistry

Positions and Employment

• 12/2004 - 09/2005: Assistant Research Scientist, School of Life Sciences, Arizona State University
• 10/2005 - 01/2011: Assistant Research Professor, School of Life Sciences, Arizona State University
• 10/2005 - 01/2011: Director, Proteomics Research Laboratory, School of Life Sciences, Arizona State University
• 01/2011 - 08/2015: Associate Professor, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy/Health Sciences, Wayne State University
• 01/2011 - present: Director, Proteomics Research Laboratory, Eugene Applebaum College of Pharmacy/Health Sciences, Wayne State University
• 08/2015 - present: Professor with tenure, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy/Health Sciences, Wayne State University
• 09/2021 - present: Director, Graduate Program, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy/Health Sciences, Wayne State University

Awards and Honors

Ongoing Research Support

NIH/NIDDK, 1R01DK128937, Duration: 04/01/2021-02/28/2025
Title: Mechanistic study of Small-molecular Therapy in diabetic Wound Healing
This study explores the molecular mechanisms of an FDA-approved oral formula of small molecules, tRES+HESP, in diabetic wound healing in cell culture and animal models.
Role: Contact-PI (Other PI: Jie-Mei Wang)

NIH/NIDDK, 1R01DK119222, Duration: 01/01/2019-12/31/2023
Title: Alleviating Reactive Carbonyl Species-Induced progenitor cell dysfunction in diabetic wound healing.
Role: Co-I (PI: Wang, Jie-Mei & Monks, Terrence J.)

Completed

NIH/NIDDK, 1R01DK107666, Duration: 9/25/2015-08/31/2021
Title: Serine/Threonine Protein Phosphatase 1 in Insulin Resistance and Type 2 diabetes
This study explores role of protein phosphatase 1 regulatory subunit 12 in human skeletal muscle insulin resistance and type 2 diabetes
Role: PI

NIH/NIDDK, 2R01DK081750 renewal of R01DK081750, Duration: 08/01/2014-4/30/2019
Title: Human Skeletal Muscle Proteome & Phosphoproteome in Obesity and Type 2 diabetes
This study explores function and regulation of protein phosphatase 2A in human skeletal muscle in obesity and type 2 diabetes.
Role: PI

Innovative Clinical or Translational Science Award # 1-16-ICTS-048
Duration: 01/01/2016-12/31/2018
American Diabetes Association
Protection against insulin resistance in obesity
The goal of this project is to identify factors responsible for protecting some obese individuals from becoming insulin resistant
Role: Co-I (PI: Jeff Horowitz, U of Michigan)

Translational Science Award #1-13-TS-27
Duration: 07/01/2013-06/30/2016
American Diabetes Association
Effect of Exercise on Human Skeletal Muscle Tyrosine Phosphoproteome
This study explores how exercise improves insulin sensitivity through novel tyrosine phosphorylation events in human skeletal muscle.
Role: PI

R56DK081750 Bridge award of R01DK081750 (PI)
Duration: 05/01/2014-7/31/2014
NIH/NIDDK
Title: Human Skeletal Muscle Proteome & Phosphoproteome in Obesity and Type 2 diabetes
This study explores function and regulation of protein phosphatase 2A in human skeletal muscle in obesity and type 2 diabetes.
Role: PI

R01DK081750
Duration: 02/01/2009-01/31/2014
NIH/NIDDK
Human Skeletal Muscle Proteome and Phosphoproteome in Obesity and Type 2 diabetes
This study explores protein-protein interactions of IRS-1 and phosphorylation of specific proteins in the PI-3 kinase insulin signaling pathway in human skeletal muscle in obesity and type 2 diabetes.
Role: PI

3R01DK081750-01A1S1
Duration: 01/15/2010-04/30/2011
NIH/NIDDK
Administrative Supplements to R01 DK081750-01A1.
Role: PI

3R01 DK081750-04S1
Duration: 02/01/2012-01/31/2013
NIH/NIDDK
Research Supplements to Promote Diversity in Health-Related Research for a postdoc-fellow
Role: PI/Mentor

Clinical/Translational Award 7-09-CT-56
Duration: 07/01/2009-06/30/2013
American Diabetes Association
Regulation of the phosphoproteome in human skeletal muscle
This research assesses global changes in protein phosphorylation under both basal and insulin stimulated conditions in insulin resistant muscle.
Role: PI

Minority Undergraduate Internship Award
Duration: 01/01/2012-12/31/2014
American Diabetes Association
Research Supplements to Promote Diversity in Health-Related Research
Role: PI/Mentor

Professional Memberships

Member- in Grant Review Panels

External
• 06/2023 Study section member, NIH/NIDDK, Human Studies of Diabetes and Obesity (HSDO)
• 05/2023 Mail reviewer, Indiana Diabetes Research Center (IDRC) Pilot and Feasibility Program
• 07/2017-06/2021 Standing study section member, NIH/NIDDK, Clinical and Integrative Diabetes and Obesity (CIDO)/Human Studies of Diabetes and Obesity (HSDO), attend the study section 3 times per year
• 01/2012-12/2020 Standing clinical study section member, American Diabetes Association's Research Grant Review Committee, attend study section once per year
• 01/18/2019 Mail reviewer, NIH/NIDDK, SPECIAL EMPHASIS PANEL, ZDK1 GRB-N (M1) PAR-18-111: High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2)
• 07/11/2018 Study section member, NIH/NIDDK, SPECIAL EMPHASIS PANEL, ZDK1 GRB-N (O4)
• 02/2015, 10/2016 Study section member, NIH/NIDDK, CIDO.
• 11/2012, 10/2014 Reviewer, American Association of College of Pharmacy (AACP)
• 03/30/2012 Study section member, NIH/NIDDK, SPECIAL EMPHASIS PANEL, ZDK1 GRB-7 (M2), PAR08-182: R24 COLLABORATIVE INTERDISCIPLINARY TEAM SCIENCE
• 02/2011 Mail reviewer, NIH/NIDDK, SPECIAL EMPHASIS PANEL, ZDK1 GRB-J (M1), PAR08-182: R24 COLLABORATIVE INTERDISCIPLINARY TEAM SCIENCE

Internal
• 01/2018, 01/2019, 05/2019 Reviewer, grant boost, Wayne State University
• 03/2015 Reviewer, pilot award, Diabetes and Obesity Team Science, Wayne State University
• 03/2015 Reviewer, interdisciplinary and interdepartmental doctoral training programs by Diabetes and Obesity Team Science, Wayne State University
• 01/2015 Reviewer, FRAP award, EACPHS, Wayne State University

Reviewers-Journals
• Arabian Journal of Chemistry
• BBA - Proteins and Proteomics
• Cardiovascular Diagnosis and Therapy
• Cell Biochemistry & Function
• Current Proteomics
• Diabetes
• Expert Review of Proteomics
• Inflammation Research
• International Journal of Biological Sciences
• Journal of Clinical Endocrinology & Metabolism
• Journal of Nutritional Biochemistry
• Journal of Proteome Research
• Journal of Proteomics
• Journal of Proteomics & Bioinformatics
• Molecules
• Nature Communications
• PLoS One
• Toxicological Sciences
• Translational Proteomics

Primary Research Interest

I have developed and maintained a vigorous independent research program (currently funded by two R01 awards by NIDDK) in the area of insulin signaling, insulin resistance, diabetes, and proteomics. Insulin resistance lies at the base of the array of diseases or pre-disease conditions such as obesity, dyslipidemia, hypertension, cardiovascular disease, type 2 diabetes, and some cancers. However, the molecular mechanisms of its pathogenesis remain elusive. Insulin regulates a wide variety of biological processes, and defects in insulin signaling in skeletal muscle are considered to be among the main causes for insulin resistance and Type 2 diabetes (T2D). T2D has become a world and US epidemic. More than 530 million adults (i.e., >10% of adults) worldwide are living with diabetes. This number is predicted to rise to 643 million by 2030 and 783 million by 2045 (https://diabetesatlas.org/). In the US, 37 million adults (i.e., 14.7% of all US adults) have diabetes, leading to >$300 billion health care costs annually.  Projections indicate that the US diabetes prevalence may increase to ~30% in 2050 (www.CDC.gov). Among all diabetic cases, more than 90% are T2D. Intracellular actions of insulin are mediated by modifications of regulatory proteins and enzymes through protein-protein interactions as well as protein phosphorylation and dephosphorylation.

My research focuses on (1). The role of novel protein-protein interactions and phosphorylation in insulin signaling in the development of skeletal muscle insulin resistance and type 2 diabetes; (2) Molecular mechanisms of an FDA-approved oral formula in diabetic wound healing. My research significantly improves our understanding of the biology of insulin signaling and the pathogenesis of insulin resistance and type 2 diabetes, and promises to discover novel drug targets to prevent and treat metabolic diseases. My research utilizes a combination of human clinical studies (directly measure human physiology/pathophysiology), in vitro cell studies (for detailed mechanistic studies), and cutting-edge proteomics (for global analysis of cell signaling & for unbiased discovery). Proteomics offers the capability to simultaneously quantify multiple proteins, protein-protein interactions, and protein phosphorylation, providing a better picture of complex protein networks.

Recent Publications

 PEER-REVIEWED PUBLICATIONS (67 in total)

*: The earliest available Impact Factors are used, which may be slightly different than the Impact Factors on the publication year due to the delay in releasing the impact factors by the Journal Citation Reports.
**: Impact Factors provided for manuscripts published after 2006.
***: Positions of the trainees in Dr. Yi group are in parenthesis. GRA: graduate research assistant, and Postdoc: Postdoc-fellow.

1. Aktham Mestareehi (GRA), Hainan Li, Xiangmin Zhang, Sai Pranathi Meda Venkata, Ruchi Jaiswal (GRA), Fu-Shin Yu, Zhengping Yi, Jie-Mei Wang, "Quantitative Proteomics Reveals Transforming Growth Factor β Receptor Targeted by Resveratrol and Hesperetin Coformulation in Endothelial Cells", ACS Omega, 2023 Apr 25;8(18):16206-16217. doi: 10.1021/acsomega.3c00678. eCollection 2023 May 9. DOI: 10.1021/acsomega.3c00678. PMID: 37179642 (Impact factor, 4.132).
2. Lana Alghanem (GRA), Xiangmin Zhang, Ruchi Jaiswal (GRA), Berhane Seyoum, Abdullah Mallisho, Zaher Msallaty, and Zhengping Yi, "Effect of Insulin and Pioglitazone on Protein Phosphatase 2A Interaction Partners in Primary Human Skeletal Muscle Cells Derived from Obese Insulin Resistant Participants", ACS Omega, 2022 Nov 15;7(47):42763-42773. doi: 10.1021/acsomega.2c04473. PMID: 36467954 (Impact factor, 4.132).
3. Kyle Jon Burghardt, Wasym Mando, Berhane Seyoum, Zhengping Yi, and Paul Ryen Burghardt, "The Effect of Antipsychotic Treatment on Hormonal, Inflammatory, and Metabolic Biomarkers in Healthy Volunteers: A Systematic Review and Meta-Analysis", Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy; First published: 04 May 2022, https://doi.org/10.1002/phar.2689, (Impact Factor: 3.737)
4. Kyle J. Burghardt, Griffin Calme, Michael Caruso (Postdoc), Bradley H. Howlett, Elani Sanders, Zaher Msallaty, Abdullah Mallisho, Berhane Seyoum, Yue A. Qi (GRA), Xiangmin Zhang and Zhengping Yi, “Profiling the Skeletal Muscle Proteome in Patients on Atypical Antipsychotics and Mood Stabilizers”, Brain Sciences, 2022, 12(2), 259. PMID: 35204022 (Impact Factor: 3.703).
5. Aktham Mestareehi (GRA), Xiangmin Zhang, Berhane Seyoum, Zaher Msallaty, Abdullah Mallisho, Kyle Jon Burghardt, Anjaneyulu Kowluru, Zhengping Yi, "Metformin Increases Protein Phosphatase 2A Activity In Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants", Journal of Diabetes Research, Volume 2021 (07/29/2021), Article ID 9979234, DOI: 10.1155/2021/9979234, PMID: 34368369. (Impact Factor: 4.011).
6. Kyle J. Burghardt, Audrey S. Khoury, Zaher Msallaty, Zhengping Yi, Berhane Seyoum, "Antipsychotic Medications and DNA Methylation in Schizophrenia and Bipolar Disorder: A Systematic Review"; Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy; 2020 Apr;40(4):331-342. DOI: 10.1002/phar.2375, PMID: 32058614 (Impact Factor: 3.045).
7. Yue Qi (GRA), Xiangmin Zhang, Berhane Seyoum, Zaher Msallaty (Postdoc), Abdullah Mallisho (Postdoc), Michael Caruso (Postdoc), Divyasri Damacharla (GRA), Danjun Ma (Postdoc), Wissam Al-janabi, Rebecca Tagett (GRA), Majed Alharbi (GRA), Griffin Calme, Aktham Mestareehi (GRA), Sorin Draghici, Abdul Abou-Samra, Anjaneyulu Kowluru, and Zhengping Yi, "Kinome profiling reveals abnormal activity of kinases in skeletal muscle from adults with obesity and insulin resistance", Journal of Clinical Endocrinology & Metabolism. 2020 Mar 1;105(3). DOI: 10.1210/clinem/dgz115, PMID: 31652310 (Impact Factor: 5.605)
8. Kyle J. Burghardt, Bradley H. Howlett, Elani J. Sanders, Sabrina E. Dass, Msallaty Z, Abdullah Mallisho, Berhane Seyoum, Zhengping Yi, “Skeletal Muscle DNA Methylation Modifications and Psychopharmacologic Treatment in Bipolar Disorder”, European Neuropsychopharmacology, 2019 Dec;29(12):1365-1373. PMID: 31635791 (Impact Factor: 4.468).
9. Divyasri Damacharla (GRA), Vijayalakshmi Thamilselvan, Xiangmin Zhang, Aktham Mestareehi (GRA), Zhengping Yi, Anjaneyulu Kowluru, “Quantitative proteomics reveals novel interaction partners of Rac1 in pancreatic β-cells: Evidence for increased interaction with Rac1 under hyperglycemic conditions”, Molecular and Cellular Endocrinology, 2019 Jun 13:110489. doi: 10.1016/j.mce.2019.110489. [Epub ahead of print]. PMID: 31202817. (Impact Factor: 3.693).
10. Hainan Li, Megan O'Meara, Xiang Zhang, Kezhong Zhang, Berhane Seyoum, Zhengping Yi, Randall Kaufman, Terrence Monks, and Jiemei Wang, "Ameliorating methylglyoxal-induced progenitor cell dysfunction for tissue repair in diabetes", Diabetes, 2019 Jun;68(6):1287-1302. doi: 10.2337/db18-0933. PMID: 30885990. (Impact Factor: 7.273).
11. Kyle J. Burghardt, Kristen M. Ward, Elani J. Sanders, Bradley H. Howlett, Berhane Seyoum, and Zhengping Yi, "Atypical Antipsychotics and the Human Skeletal Muscle Lipidome", Metabolites, 2018, 8(4), 64; DOI: 10.3390/metabo8040064, PMID: 30322152. (Impact Factor: 3.303).
12. Kyle J. Burghardt, Berhane Seyoum, Abdullah Mallisho, Elani Sanders, Zhengping Yi, "Protein Kinase B (AKT) DNA Hypermethylation with Maintenance Atypical Antipsychotic Treatment in Participants with Bipolar Disorder", Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2018 Apr;38(4):428-435, PMID: 29484683. (Impact Factor: 2.932).
13. Kyle J. Burghardt, Berhane Seyoum, Abdullah Mallisho, Paul Burghardt, Reno Kowluru, Zhengping Yi, "Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies", Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2018 Apr 20;83:55-63. doi: 10.1016/j.pnpbp.2018.01.004. Epub 2018 Jan 8. PMID: 29325867. (Impact Factor: 4.187, 5-year Impact Factor: 4.131).
14. Xitao Xie, Sandeep Sinha, Zhengping Yi, Paul Langlais, Meenu Madan, Benjamin Bowen, Wayne Willis, and Christian Meyer, "Role of Adipocyte Mitochondria in Inflammation, Lipemia and Insulin Sensitivity in Humans: Effects of Pioglitazone Treatment", International Journal of Obesity, 2017, 1-8, doi: 10.1038/ijo.2017.192. PMID: 29087390. PMCID: PMC6021211 (Impact Factor: 5.487).
15. Otto Muzik, Paul Burghardt; Zhengping Yi; Ajay Kumar; Berhane Seyoum, "Successful metformin treatment of insulin resistance is associated with down-regulation of the kynurenine pathway", Biochemical and Biophysical Research Communications, 2017 Jun 17;488(1):29-32. doi: 10.1016/j.bbrc.2017.04.155. (Impact Factor: 2.371, 5-year Impact Factor: 2.392).
16. Kai Wu, Lingzhi Li, Chitra Thakur, Yongju Lu, Xiangmin Zhang, Zhengping Yi & Fei Chen, "Proteomic Characterization of the World Trade Center dust-activated mdig and c-myc signaling circuit linked to multiple myeloma", Scientific Reports, 2016, Nov 11;6;36305. Doi: 10.1038/srep36305. (Impact Factor: 5.228, 5-year impact factor: 5.525).
17. Xitao Xie, Zhengping Yi, Sandeep Sinha, Meenu Madan, Benjamin P. Bowen, Paul Langlais, Danjun Ma (Postdoc), Lawrence Mandarino, and Christian Meyer, "Proteomics Analyses of Subcutaneous Adipocytes Reveal Novel Abnormalities in Human Insulin Resistance". Obesity (Silver Spring). 2016 Jul;24 (7):1506-14. doi: 10.1002/oby.21528. PMID: 27345962. (Impact Factor: 3.614).
18. Xiangmin Zhang, Divyasri Damacharla (GRA), Danjun Ma (Postdoc), Yue Qi (GRA), Rebecca Tagett (GRA), Sorin Draghici, Anjaneyulu Kowluru, and Zhengping Yi, "Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic beta-cells", Molecular and Cellular Endocrinology, 2016, 424, 1-11. PMID: 26780722 (Impact Factor: 4.41, 5-Year Impact Factor: 4.11).
19. Michael Caruso (Postdoc), Xiangmin Zhang, Danjun Ma (Postdoc), Zhao Yang (GRA), Yue Qi (GRA), and Zhengping Yi, “Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts", PLosOne, 2015 Oct 14;10(10):e0140255. doi: 10.1371/journal.pone.0140255. eCollection 2015. PMID: 26465754. (Impact Factor: 3.23).
20. Chengjian Tu, Quanhu Sheng, Jun Li, Danjun Ma (Postdoc), Xiaomeng Shen, Xue Wang, Yu Shyr, Zhengping Yi, and Jun Qu, "Optimization of Search Engines and Postprocessing Approaches to Maximize Peptide and Protein Identification for High-Resolution Mass Data", Journal of Proteome Research, 2015 Nov 6;14(11):4662-73. doi: 10.1021/acs.jproteome.5b00536. Epub 2015 Sep 30. PMID: 26390080. (Impact Factor: 4.25).
21. Wei Wang, Yongju Lu, Paul M. Stemmer, Xiangmin Zhang, Yongyi Bi, Zhengping Yi, Fei Chen, "The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair", Oncotarget, 2015 Sep 29;6(29):28269-81. doi: 10.18632/oncotarget.4961 Epub July 22, 2015. (Impact factor: 6.359).
22. Feven Berhane, Alemu Fite, Nour Daboul, Wissam Al-Janabi, Zaher Msallaty (Postdoc), Michael Caruso (Postdoc), Monique K. Lewis (Postdoc), Zhengping Yi, Michael P. Diamond, Abdul-Badi Aboul-Samra, and Berhane Seyoum, "Plasma lactate levels increase during hyperinsulinemic euglycemic clamp and oral glucose tolerance test", Journal of Diabetes Research, 2015, 2015;2015:102054. doi: 10.1155/2015/102054. Epub 2015 Apr 19. PMID: 25961050. (Impact Factor 3.536, 5-year Impact Factor 3.278).
23. Michael Caruso (Postdoc), Danjun Ma (Postdoc), Zaher Msallaty (Postdoc), Monique K. Lewis (Postdoc), Berhane Seyoum, Wissam Al-janabi, Michael Diamond, Abdul B. Abou-Samra, Kurt Hojlund, Rebecca Tagett (GRA), Sorin Draghici, Xiangmin Zhang, Jeffrey F. Horowitz, and Zhengping Yi, “Increased Interaction with Insulin Receptor Substrate-1, a Novel Abnormality in Insulin Resistance and Type 2 Diabetes”, Diabetes, 2014, Jun., 63, 1933-1947, Epub 2014 Feb. PMID: 24584551. (Impact Factor 7.895, 5-year Impact Factor: 8.611).
24. Xiangmin Zhang, Danjun Ma (Postdoc), Michael Caruso (Postdoc), Monique K. Lewis (Postdoc), Yue Qi (GRA), and Zhengping Yi, “Quantitative Phosphoproteomics Reveals Novel Phosphorylation Events in Insulin Signaling Regulated by Protein Phosphatase 1 Regulatory Subunit 12A”, Journal of Proteomics, 2014, 109, 23 September, 63–75. Epub 2014 Jun 24. PMID: 24972320. (Impact factor: 4.088, 5-year impact factor: 4.302).
25. Bailing Chen, Miaomiao Yu, Qingshan Chang, Yongju Lu, Chitra Thakur, Danjun Ma (Postdoc), Zhengping Yi, and Fei Chen, "Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin”, Oncotarget, 2013 Sep;4(9):1427-37. Aug 10. [Epub ahead of print]. PMID: 23965803. (Impact factor: 6.636, 5-year impact factor: 6.636).
26. Mohammad A Qasim, Lixia Wang, Sabiha Qasim, Stephen Lu, Wuyuan Lu, Michael Ranjbar, Richard Wynn, Zhengping Yi, and Michael Laskowski Jr, “Additivity-based design of the strongest possible turkey ovomucoid third domain inhibitors for porcine pancreatic elastase (PPE) and Streptomyces griseus protease B (SGPB)”, FEBS Letters, 2013 Sep 17;587(18):3021-6. Epub 2013 Jul 23. PMID: 23892073. (Impact factor: 3.582, 5-year impact factor: 3.478).
27. Sophie E. Hussey, Carrie G. Sharoff, Andrew Garnham, Zhengping Yi, Benjamin Bowen, Lawrence J. Mandarino and Mark Hargreaves, "Effect of Exercise on the Skeletal Muscle Proteome in Patients with Type 2 Diabetes", Medicine and Science in Sports and Exercise, 2013 Jun;45(6):1069-76. Epub 2012 Dec 27. PMID: 23274603. (Impact Factor: 4.43; 5-Year Impact Factor: 5.02).
28. Xiao‐Wei Chen, He Wang, Kanika Bajaj, Pengcheng Zhang, Zhouxian Meng, Danjun Ma (Postdoc), Yongsheng Bai, Elizabeth Adams, Andrea Baines, Genggeng Yu, Maureen A. Sartor, Bin Zhang, Zhengping Yi, Jiandie Lin, Stephen G. Young, Randy Schekman, and David Ginsburg, "SEC24A Deficiency Lowers Plasma Cholesterol through Reduced PCSK9 Secretion", eLife, 2013 Apr 9;2:e00444. (Impact factor: 8.519, 5-year impact factor: 8.556).
29. Kimberly Pham, Paul Langlais, Xiangmin Zhang, Alex Chao, Morgan Zingsheim and Zhengping Yi, “Insulin-stimulated Phosphorylation of Protein Phosphatase 1 Regulatory Subunit 12B Revealed by HPLC-ESI-MS/MS”, Proteome Science, 2012 Sep 1;10(1):52. Epub 2012, Sept 1. (Impact Factor: 2.328; 5-Year Impact Factor: 2.565).
30. Thangiah Geetha, Paul Langlais, Michael Caruso (Postdoc), and Zhengping Yi, “Protein Phosphatase 1 Regulatory Subunit 12A and Catalytic Subunit, new members in the phosphatidylinositide 3-kinase Insulin Signaling Pathway”, Journal of Endocrinology, 2012 Sep; 214(3):437-43. Epub 2012 Jun 22. PMID: 22728334. (Impact factor: 3.548, 5-year impact factor: 3.175).
31. Xiangmin Zhang, Kurt Højlund, Moulun Luo, Christian Meyer, Geetha Thangiah, and Zhengping Yi, “Novel Tyrosine Phosphorylation Sites in Rat Skeletal Muscle Revealed by Phosphopeptide Enrichment and HPLC-ESI-MS/MS”, Journal of Proteomics, 2012 Jul 16;75(13):4017-26. Epub 2012 May 18. PMID: 22609512. (Impact Factor: 5.074; 5-Year Impact Factor: 5.080).
32. Alex Chao; Xiangmin Zhang; Danjun Ma (Postdoc); Paul Langlais; Moulun Luo, Lawrence J. Mandarino, Morgan Zingsheim; Kimberly Pham; James Dillon, Zhengping Yi, “Site-Specific Phosphorylation of Protein Phosphatase 1 Regulatory Subunit 12A Stimulated or Suppressed by Insulin”, Journal of Proteomics, Jun 18;75(11):3342-50. Epub 2012, April 6. PMID: 22516431. (Impact Factor: 5.074; 5-Year Impact Factor: 5.080).
33. Sarah Everman, Zhengping Yi, Paul Langlais, Lawrence J. Mandarino, Moulun Luo, Christine Roberts, and Christos S. Katsanos, "Measurement of Stable-Isotope Enrichment of in Vivo Labeled Muscle ATP Synthase Beta Subunit Using HPLC-ESI-MS/MS", PLoS One. 2011; 6(10):e26171. Epub 2011 Oct 12. PMID: 22022551. (Impact Factor: 4.411; 5-Year Impact Factor: 4.610).
34. Paul Langlais, Zhengping Yi, Jean Finlayson, Moulun Luo, Rebekka Mapes Holmes, Elena A. De Filippis, Christian Meyer, E. Plummer, P. Tongchinsub, Mark Mattern, Lawrence J. Mandarino, “Global IRS-1 phosphorylation analysis in insulin resistance”, Diabetologia, 2011 Nov;54(11):2878-89. Epub 2011, Aug 18. PMID: 21850561. (Impact Factor: 6.973; 5-Year Impact Factor: 6.227).
35. Rebekka Mapes Holmes, Zhengping Yi, Elena A. De Filippis, Rachele Berria, Sadeka Shahani, Padma Sathyanarayana, Vadim Sherman, Kentaro Fujiwara, Christian Meyer, Christine Christ-Roberts, Hyonson Hwang, Jean Finlayson, Lilly. Q. Dong, Lawrence J. Mandarino, and Mandeep Bajaj, "Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling", Diabetologia, 2011 Aug; 54(8):2122-31. Epub 2011 May 12. PMID: 21562756. (Impact Factor: 6.973; 5-Year Impact Factor: 6.227).
36. Paul Langlais, Zhengping Yi, Lawrence J. Mandarino, “The Identification of Raptor as a Substrate for P44/42 MARK”, Endocrinology, 2011 Apr; 152(4):1264-73. Epub 2011 Feb 15. PMID: 21325048. (Impact Factor: 4.993; 5-Year Impact Factor: 5.265.
37. Thangiah Geetha, Paul Langlais, Moulun Luo, Rebekka Mapes, Natalie Lefort, Shu-Chuan Chen, Lawrence J. Mandarino1 and Zhengping Yi, "Label-free Proteomic Identification of Endogenous, Insulin-stimulated Interaction Partners of Insulin Receptor Substrate-1", Journal of the American Society for Mass Spectrometry, 2011 Mar;22(3):457-66. Epub 2011 Jan 29. PMID: 21472564. (Impact Factor: 3.830; 5-Year Impact Factor: 3.625).
38. Lopes LB, Brophy CM, Flynn CR, Zhengping Yi, Bowen BP, Smoke C, Seal B, Panitch A, Komalavilas P., “A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model”, Journal of Vascular Surgery. 2010 Dec; 52(6):1596-607. Epub 2010 Sep 22. (Impact Factor: 3.853; 5-Year Impact Factor: 3.983).
39. Natalie Lefort, Benjamin P. Bowen, Brian Glancy, Elena A. De Filippis, Rebekka Mapes, Hyonson Hwang, Charles R. Flynn, Wayne T. Willis, Anthony Civitarese, Kurt Hojlund, Zhengping Yi, and Lawrence J. Mandarino, “Increased ROS production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin resistant human skeletal muscle”, Diabetes, 2010 Oct; 59(10):2444-52. Epub 2010 Aug 3. (Impact Factor: 8.889; 5-Year Impact Factor: 8.484).
40. Xitao Xie, Zhengping Yi, Benjamin Bowen, Cassandra Wolf, Charles R. Flynn, Sandeep Sinha, Lawrence J. Mandarino, and Christian Meyer, “Characterization of the Human Adipocyte Proteome and Reproducibility of Protein Abundance by One-dimensional Gel Electrophoresis and HPLC-ESI-MS/MS”, Journal of Proteome Research, 2010 Sep 3;9(9):4521-34. PMID: 20812759. (Impact Factor: 5.460; 5-Year Impact Factor: 5.617).
41. Paul Langlais, Lawrence J. Mandarino, and Zhengping Yi, “Label-free Relative Quantification of Co-eluting Isobaric Phosphopeptides of Insulin Receptor Substrate-1 by HPLC-ESI-MS/MS”, Journal of the American Society for Mass Spectrometry, 2010 Sep;21(9):1490-9. Epub 2010 Jun 9. PMID: 20594869. (Impact Factor: 3.830; 5-Year Impact Factor: 3.625).
42. Kurt Hojlund, Zhengping Yi, Natalie Lefort, Paul Langlais, Benjamin P. Bowen, Klaus Levin, Henning Beck-Nielsen, and Lawrence J. Mandarino, “Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle”, Diabetologia, 2010 Mar;53(3):541-51. PMID: 20012595. (Impact Factor: 6.973; 5-Year Impact Factor: 6.227).
43. Hyonson Hwang, Benjamin P. Bowen, Natalie Lefort, Charles R. Flynn, Elena A. De Filippis, Christine Roberts, Chris Smoke, Christian Meyer, Kurt Hojlund, Zhengping Yi, and Lawrence J. Mandarino, “Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes Mellitus”, Diabetes, 2010 Jan;59(1):33-42. PMID: 19833877. (Impact Factor: 8.889; 5-Year Impact Factor: 8.484).
44. Kurt Hojlund, Benjamin P. Bowen, Hyonson Hwang, Charles R. Flynn, Lohith Madireddy, Thangiah Geetha, Paul Langlais, Christian Meyer, Lawrence J. Mandarino, and Zhengping Yi, “In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS”, Journal of Proteome Research, 2009 Nov;8(11):4954-65. PMID: 19764811. (Impact Factor: 5.460; 5-Year Impact Factor: 5.617).
45. Natalie Lefort, Zhengping Yi, Benjamin P. Bowen, Brian Glancy, Elena A. De Filippis, Rebekka Mapes, Hyonson Hwang, Charles R. Flynn, Wayne T. Willis, Anthony Civitarese, Kurt Hojlund, and Lawrence J. Mandarino, “Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS”, Journal of Proteomics, 2009 Aug 20;72(6):1046-60. Epub 2009 Jun 28. PMID: 19567276. (Impact Factor: 5.074; 5-Year Impact Factor: 5.080).
46. Zhengping Yi, Benjamin P. Bowen, Hyonson Hwang, Christopher P. Jenkinson, Dawn K. Coletta, Natalie Lefort, Mandeep Bajaj, Sangeeta Kashyap, Rachele Berria, Elena A. De Filippis, and Lawrence J. Mandarino, "Global Relationship between the Proteome and Transcriptome of Human Skeletal Muscle", Journal of Proteome Research, 2008 Aug; 7(8):3230-41. Epub 2008 Jul 10. PMID: 18613714. (Impact Factor: 5.460; 5-Year Impact Factor: 5.617).
47. Kurt Højlund, Zhengping Yi, Hyonson Hwang, Benjamin P. Bowen, Natalie Lefort, Charles R. Flynn, Paul Langlais, Susan T. Weintraub, and Lawrence J. Mandarino, "Characterization of the Human Skeletal Muscle Proteome by One-dimensional Gel Electrophoresis and HPLC-ESI-MS/MS", Molecular & Cellular Proteomics, 2008 Feb;7(2):257-67. Epub 2007 Oct 1. PMID: 17911086. (Impact Factor: 8.354; 5-Year Impact Factor: 9.392).
48. Zhengping Yi, Paul Langlais, Elena A. De Filippis, Moulun Luo, Charles R. Flynn, Stefanie Schroeder, Susan T. Weintraub, Rebekka Mapes, and Lawrence J. Mandarino, “Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle”, Diabetes. 2007 Jun; 56(6):1508-16. Epub 2007 Mar 14. PMID: 17360977. (Impact Factor: 8.889; 5-Year Impact Factor: 8.484).
49. Moulun Luo, Paul Langlais, Zhengping Yi, Natalie Lefort, Elena A. De Filippis, Hyonson Hwang, Christine Y. Christ-Roberts, and Lawrence J. Mandarino, “Phosphorylation of Human IRS-1 at Ser629 Plays a Positive Role in Insulin Signaling”, Endocrinology. 2007 Oct; 148(10):4895-905. Epub 2007 Jul 19. PMID: 17640984. (Impact Factor: 4.993; 5-Year Impact Factor: 5.265).
50. Tiana C. White, Zhengping Yi and Brenda G. Hogue, “Identification of Mouse Hepatitis Coronavirus A59 Nucleocapsid Protein Phosphorylation Sites”, Virus Research, 2007 Jun; 126(1-2):139-48. (Impact Factor: 2.905; 5-Year Impact Factor: 2.846).
51. Charles R. Flynn, Christopher C. Smoke, Elizabeth Furnish, Padmini Komalavilas, Jeffrey Thresher, Zhengping Yi, Lawrence J. Mandarino, Colleen M. Brophy, “Phosphorylation and activation of a transducible recombinant form of human HSP20 in E. coli”, Protein Expression and Purification, 2007, 52, 50–58. Epub 2006 Sep 12. PMID: 17084643.
52. Zhengping Yi, Moulun Luo, Sara M. Reyna, Christopher A. Carroll, Susan T. Weintraub, and Lawrence J. Mandarino, “Quantification of Phosphorylation of Insulin Receptor Substrate-1 by HPLC-ESI/MS/MS”, Journal of the American Society for Mass Spectrometry, 2006, 17(4), 562-7. Epub 2006 Feb 28. PMID: 16503154.
53. Zhengping Yi, Olga Vitek, M. A. Qasim, Stephen M. Lu, Wuyuan Lu, Michael Ranjbar, Jiangtian Li, Michael C. Laskowski, Chris Bailey-Kellogg, and Michael Laskowski, Jr., “Functional Evolution within a Protein Superfamily”, Proteins-Structure, Function, and Bioinformatics, 2006, 63(3),697-708.
54. Zhengping Yi, M. A. Qasim, Sabiha Qasim, Terrell L. Warrington, and M. Laskowski, Jr. “Ring-Toss. Capping hyperexposed tyrosyl or tryptophyl residues in proteins by beta-cyclodextrin”, Biochimica and Biophysica Acta-General Subjects, 2006, 1760, 372-379.
55. Zhengping Yi, Moulun Luo, Christopher Carroll, Susan T. Weintraub, and Lawrence J. Mandarino, “Identification of Phosphorylation Motifs in Insulin Receptor Substrate (IRS)-1 by Hypothesis-Driven HPLC-ESI/MS/MS”, Analytical Chemistry, 2005, 77, 5693-5699. PMID: 16131083.
56. Moulun Luo, Sara Reyna, Lishan Wang, ZhengPing Yi, Christopher Carroll, Lily Q. Dong, Paul Langlais, Susan T. Weintraub, and Lawrence J. Mandarino, “Identification of IRS-1 Serine/Threonine Phosphorylation Sites Using Mass Spectrometry Analysis; Regulatory Role of Serine 1223”, Endocrinology, 2005, 146, 4410-4416. Epub 2005 Jul 14. PMID: 16020478.
57. Jiangtian Li, ZhengPing Yi, Michael Laskowski, Jr., Christopher J. Bailey-Kellogg, "Analysis of sequence-reactivity space for protein-protein interactions", Proteins-Structure, Function, and Bioinformatics, 2005, 58(3):661-671
58. Michael Laskowski, Jr., M. A. Qasim and ZhengPing Yi, "Additivity-based prediction of equilibrium constants for some protein–protein associations", Current Opinion in Structural Biology, 2003, Vol. 13 (1), 130-139.
59. M.A. Qasim, Wuyuan Lu, Stephen M. Lu, Michael Ranjbar, ZhengPing Yi, YiWen Chiang, Kevin Ryan, Stephen Anderson, Wenlei Zhang, Sabiha Qasim, and Michael Laskowski, Jr., “Testing of the Additivity Based Protein Sequence to Reactivity Algorithm”, Biochemistry, 2003, Vol. 42, 6460-6466.
60. Zheng-Ping Yi, Ju Hu, and Hui-Lan Chen, "The comparison of the orientation of sodium 3-hydroxy-2-naphtalenecarboxy-late anion in the cavity of beta-cyclodextrin and heptakis- (2, 3, 6-tri-o-methyl)-beta-cyclodextrin", Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2003, Vol. 45, 1-7.
61. Zheng-Ping Yi, Hui-Lan Chen, Zhengzi Huang, Qing Huang, and Jun-Sheng Yu, “Contributions of weak interactions to the Inclusion Complexation of 3-Hydroxy -2-Naphthalenecarboxylic Acid and It’s Analogues with Cyclodextrins”, Journal of The Chemical Society-Perkin Transactions 2, 2000, 121.
62. Zheng-Ping Yi, Ju Hu, Qing Huang, and Hui-Lan Chen, “Conformational Analysis of the Inclusion Complex of 3-Hydroxy-2-Naphthalenecarboxylate Anion with Heptakis- (2, 3, 6-tri-o-methyl)-beta-Cyclodextrin in D2O by 2D 1HNMR”, Spectroscopy Letters, 2000, Vol. 33, 407.
63. Zheng-Ping Yi, Jian-Ping Zou, Yang, Hui-Lan Chen, and Xi-Mao Bao, “The investigation of Si-based Nanoporous Alumina Film-Sodium 3-Hydroxy-2- Naphthalenecarboxylate Fluorescent Compound Material”, Chinese Journal of Semiconductors, 2000, Vol. 21(8), 770.
64. Zhengping Yi, Changchun Zhao, Zhengzi Huang, Huilan Chen, and Junsheng Yu, "Investigation of Buffer-Cyclodextrin System", Physical Chemistry Chemical Physics, 1999, Vol. 1, 441.
65. Zhengping Yi, Zhengzi Huang, Junsheng Yu, and Huilan Chen, “Be Careful When You Want to Use Buffers in Aqueous Solutions of Cyclodextrins. Effect of Buffers on the Formation Constants of 3-Hydroxy-2-Naphthoic Acid with Beta- Cyclodextrin”, Chemistry Letters, 1998, 1161.
66. Zhengping Yi, Changchun Zhao, Huilan Chen, and Junsheng Yu, “Effect of pH values on the formation constants of 3-Hydroxy-2-Naphthoic Acid with Beta-Cyclodextrin”, Chinese Journal of Inorganic Chemistry, 1997, Vol.13, 164.
67. Zhi-Lin Wang, Zheng-Ping Yi, Tian Li, Ying Chen, Zhi-Ming Huang, Gui-Di Yang, De-Ping Xue and Hui-Lan. Chen, “Studies on coenzyme B-12 model complexes.8. The characterization of products of photochemical reactions of oxygen insertion into Co-C bond of RCo (Salen) L complexes,” Chemical Journal of Chinese Universities-Chinese, 1996, Vol.17, 21.

Quote

“Love what you do and do what you love"

Quote Attribution

Ray Bradbury

DO NOT EDIT: Experts guide blurb

Zhengping Yi is an expert in insulin resistance and type 2 diabetes, studying the disease both clinically and with mass spectrometry and proteomics.

Research Description

Affiliated Departments

• Pharmaceutical Science