Mai Lam

Phone

(313) 577-0118

Biography

• Associate Professor, Department of Biomedical Engineering, Wayne State University, Detroit, MI. 2023-Present
• Assistant Professor, Department of Biomedical Engineering, Wayne State University, Detroit, MI. 2013-2023
• Assistant Professor, Cardiovascular Research Institute, School of Medicine, Wayne State University, Detroit, MI. 2014-2020
• Postdoctoral Scholar, Cardiovascular Institute and the Stem Cell Institute for Regenerative Medicine, Stanford University, Stanford, CA. 2008-2013

Dr. Lam is an expert in cardiovascular tissue engineering and stem cell regenerative medicine. Her research focuses on tissue engineering of blood vessels and application of her engineered vessels towards patient-specific grafts and as disease models. She graduated with Honors from the University of Michigan and has received 2 Teaching Awards while at WSU. She completed postdoctoral training in two top labs at Stanford University under the direction of Drs. Joseph Wu (Cardiovascular/Stem Cells) and Michael Longaker (Stem Cells/Regenerative Medicine). The goal of her lab is to create a new and better option for a vascular graft to treat patients suffering from vascular disease, and to discover new treatment targets by creating tissue engineered disease models.

Research Interests

• Tissue Engineering and Regenerative Medicine
• Biomaterials Applications
• Cardiac and Musculoskeletal Systems
• Stem Cell Differentiation and Transplantation
• Cellular and Tissue Biomechanics
• Extracellular Matrix Interactions
• Cell adhesion
• Translational Studies 

Courses Taught

• BME 4010 Physiology Laboratory
• BME 5220 Cellular and Tissue Biomechanics
• BME 5380 Biocompatibility

Publications

(Selected)

Wonski BT, Patel B, Tepper DG, Siddiqui A, Kabbani LS, Lam MT. Adipose-derived stem cells significantly increases collagen level and fiber maturity in patient-specific biological engineered blood vessels. PLoS One. 2023 Sep 22;18(9):e0291766.

Wonski BT, Fisher B, Lam MT. Assessment of biocompatible hydrogels to augment mechanical structure in tissue engineered blood vessels. Bioengineering (Basel). 2023 Jun 30;10(7):780.

Patel B, Wonski BT, Saliganan DM, Rteil A, Kabbani LS, Lam MT. Decellularized dermis extracellular matrix alloderm mechanically strengthens biological engineered tunica adventitia-based blood vessels. Sci Rep. 2021 May 31;11(1):11384.

Patel B, Xu Z, Pinnock CB, Kabbani LS, Lam MT. Self-assembled Collagen-Fibrin Hydrogel Reinforces Tissue Engineered Adventitia Vessels Seeded with Human Fibroblasts. Sci Rep. 2018 Feb 19;8(1):3294.

Lam MT. Mesenchymal Stem Cell Therapies for Skin Repair and Regeneration. Journal of Dermatology & Cosmetology. J Dermat Cosmetol. 2017, 1(3): 00014.

Wang L, Meier E, Tian S, Lei I, Liu L, Xian S, Lam MT, Wang Z. Transplantation of Isl1+ cardiac progenitor cells in small intestinal submucosa improves infarcted heart function. Stem Cell Res Ther. 2017 Oct 16;8(1):230.

Pinnock CB, Xu Z, Lam MT. Scaling of Engineered Vascular Grafts using 3D Printed Guides and the Ring Stacking Method. J Vis Exp. (Invited). 2017 Mar 27;(121).

Pinnock CB, Meier EM, Joshi N, Wu B, Lam MT. Customizable Engineered Blood Vessels Using 3D Printed Inserts. Methods (Special issue-Invitation only). Guest editors: Anthony Atala & Hooman Sadri-Ardekani. 2016;15(99):20-7.

Xu Z and Lam MT, “Alginate Application for Heart and Cardiovascular Diseases,” book chapter 14, in Springer Series in Biomaterials Science and Engineering. Volume: Alginates and their Biomedical Applications. Eds: BHA Rehm, F Moradali. Springer. 2016.

Meier EM and Lam MT. Role of mechanical stimulation in stem cell differentiation. JSM Biotechnol Bioeng. 2016, 3(3): 1060.

Meier EM, Wu B, Siddiqui A, Tepper DG, Longaker MT, Lam MT. Mechanical Stimulation Increases RNA-level Expression of Knee Meniscus Genes in Adipose-derived Stromal Cells. Plast Reconstr Surg GO. 2016 16;4(9):e864.

Awards and Honors

• Global Learning Faculty Fellow, Wayne State University, 2023
• Excellence in Teaching Award, College of Engineering, Wayne State University, 2018
• Outstanding Faculty Award, College of Engineering, Wayne State University, 2015
• Multi-Disciplinary Training Program in Cardiovascular Imaging at Stanford (CVIS) Postdoctoral Fellowship (T32), 2011
• Summer Institute for Entrepreneurship Certificate, Graduate School of Business (GSB), Stanford University, 2011
• Stanford GSB Summer Institute for Entrepreneurship Fellow Award for Exemplary Performance, 2011
• Henzl-Gabor Young Women in Science Travel Fellowship, 2010
• Kathleen McCormick Committee to Support Women in Medical Careers Postdoctoral Travel Grant, 2010
• Ethelmae Haldan Grant for Innovative Science in Osteoarthritis, Arthritis National Research Foundation, 2009-2010
• National Institute on Aging (NIA) Multidisciplinary Training in Aging Research Fellow, 2004-2006
• Engineering Academic Scholar, College of Engineering, University of Michigan, 2006
• Best Overall Poster Award, Annual Society of Women Engineers (SWE) Poster Competition, 2005
• University Honors, 2001

Education

B.S.E. with Honors, Materials Science and Engineering, University of Michigan, Ann Arbor, MI
M.S.E., Biomedical Engineering, University of Michigan, Ann Arbor, MI
Ph.D., Biomedical Engineering, University of Michigan, Ann Arbor, MI

Laboratory Web Site

 Vascular Regeneration and Mechanics Lab

Research Description

Affiliated Departments

• Biomedical Engineering