| Faculty Profile |
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Phone
313-577-3473
Office
Department of Biological Sciences, Rm 2109/Rm 2177
Selected publications
Mishra, S., Dabaja, M., Akhlaq, A., Pereira, B., Marbach, K., Rovcanin, M., Chandra, R., Caballero, A., Fernandes de Abreu, D., Ch'ng, Q., and Alcedo, J. (2023). Specific sensory neurons and insulin-like peptides modulate food type-dependent oogenesis and fertilization in Caenorhabditis elegans. eLife 12, e83224. (Research article)
Sifoglu, D., and Alcedo, J. (2022). Homme fatal: how males cause demise. Nat Aging 2, 773-774. (News and Views)
Alcedo, J., and Prahlad, V. (2020). Neuromodulators: an essential part of survival. J Neurogenet 34. doi: 10.1080/01677063.2020.1839066.
Wu, T., Duan, F., Yang, W., Liu, H., Caballero, A., Fernandes de Abreu, D.A., Dar, A.R., Alcedo, J., Ch’ng, Q.L., Butcher, R.A., and Zhang, Y. (2019). Pheromones modulate learning by regulating the balanced signals of two insulin-like peptides. Neuron 104, 1095-1109.
Ewald, C.Y., Hourihan, J.M., Bland, M.S., Obieglo, C., Katic, I., Moronetti Mazzeo, L.E., Alcedo, J., Blackwell, T.K., and Hynes, N.E. (2017). NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans. eLife 6, e19493.
Artan, M., Jeong, D.E., Lee, D., Kim, Y.I., Son, H.G., Husain, Z., Kim, J., Altintas, O., Kim, K., Alcedo, J., and Lee, S.J. (2016). Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides. Genes Dev. 30, 1047-1057.
Ostojic, I., Boll, W., Waterson, M.J., Chan, T., Chandra, R., Pletcher, S.D., and Alcedo, J. (2014). Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling. Proc. Natl. Acad. Sci. USA 111, 8143-8148.
Waterson, M.J., Chung, B.Y., Harvanek, Z.M., Ostojic, I., Alcedo, J., and Pletcher, S.D. (2014). Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling. Proc. Natl. Acad. Sci. USA 111, 8137-8142.
Fernandes de Abreu, D.A.*, Caballero, A.*, Fardel, P., Stroustrup, N., Chen, Z., et al., Antebi, A.+, Blanc, E.+, Apfeld, J.+, Zhang, Y.+, Alcedo, J.+, and Ch’ng, Q.L.+ (2014). An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. PLoS Genet 10, e1004225. *:Equal contributions. +:Co-corresponding authors.
Chen, Z., Hendricks, M., Cornils, A., Maier, W., Alcedo, J., and Zhang, Y. (2013). Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans. Neuron 77, 572-585.
Cornils, A., Gloeck, M., Chen, Z., Zhang, Y., and Alcedo, J. (2011). Specific insulin-like peptides encode sensory information to regulate distinct developmental processes. Development 138, 1183-1193.
Fierro-Gonzalez, J. C., Cornils, A., Alcedo, J., Vizuete, A. M.+, and Swoboda, P.+ (2011). The thioredoxin TRX-1 modulates the function of an insulin-like neuropeptide during dauer formation in Caenorhabditis elegans. PLoS One 6, e16561. +: Co-corresponding authors
Maier, W.*, Adilov, B.*, Regenass, M., and Alcedo, J. (2010). A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol 8, e1000376. *: Equal contributions.
Noll, H., Alcedo, J., Frei, E., Hunt, J., Matranga, V., Hochstrasser, M., Aebersold, R., Newitt, R., and Noll, M. (2007). The major cell adhesion glycoprotein of the sea urchin embryo is an ironless, calcium-binding member of the transferrin family. Dev. Biol. 310, 54-70.
Alcedo, J., and Kenyon, C. (2004). Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41, 45-55. Cover; Featured article. (Previewed by Adam Antebi (2004). Long life: a matter of taste (and smell). Neuron 41, 1-3.)
Alcedo, J.*, Zou, Y.*, and Noll, M. (2000). Posttranscriptional regulation of Smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Mol. Cell 6, 457-465. *: Equal contributions.
Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M., and Hooper, J. E. (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell 86, 221-232.