Jessica Damoiseaux


Faculty Profile

Associate Professor




 87 East Ferry St., room 255 Knapp Building


Jessica Damoiseaux, Ph.D., is an Associate Professor in the Institute of Gerontology and the Department of Psychology. Dr. Damoiseaux' main research goal is to understand the changes in brain function and cognition that accompany normal and abnormal aging. She is particularly interested in examining the influence of biological and cognitive predisposition on cognitive and brain network connectivity changes in healthy older adults. The primary approach Dr. Damoiseaux uses to study brain network connectivity is functional magnetic resonance imaging (fMRI). In addition, she uses other neuroimaging techniques, such as structural MRI and diffusion imaging to study brain structure and structural brain connectivity.

Selected publications

• Viviano RP, Damoiseaux JS, 2020. Functional Neuroimaging in Subjective Cognitive Decline: Current Status and a Research Path Forward. Alzheimer's Research & Therapy 12 (1), 1-18.
• Crane NT, Hayes JM, Viviano RP, Bogg T, Damoiseaux JS, 2020. Resting-state functional brain connectivity in a predominantly African-American sample of older adults: Exploring links among personality traits, cognitive performance, and the default mode network. Personality Neuroscience 3.
• Liem F, Geerligs L, Damoiseaux JS, Margulies DS. Functional Connectivity in Aging. Chapter to be published in Schaie, KW & Willis, S, Handbook of the Psychology of Aging, 9th edition 2020. Available online as preprint via
• Gothe NP, Kahn I, Hayes JM, Erlenbach E, Damoiseaux JS, 2019. Yoga Effects on Brain Health: A Systematic Review of the Current Literature. Brain Plasticity 5, 105-122.
• Viviano RP, Hayes JM, Pruitt PJ, Fernandez Z, van Rooden S, van der Grond J, Rombouts SA, Damoiseaux JS, 2019. Aberrant memory system connectivity and working memory performance in subjective cognitive decline. NeuroImage185, 556-564.
• van Rooden S, van den Berg-Huysmans AA, Croll PH, Labadie G, Hayes JM, Viviano RP, van der Grond J, Rombouts SA, Damoiseaux JS, 2018. Subjective cognitive decline is associated with greater white matter hyperintensity volume. J Alzheimers Dis. 1-12.
• Morris, A., Ravishankar, M., Pivetta, L., Chowdury, A., Falco, D., Damoiseaux, J.S., Rosenberg, D.R., Bressler, S.L., Diwadkar, V.A., 2018. Response Hand and Motor Set Differentially Modulate the Connectivity of Brain Pathways During Simple Uni-manual Motor Behavior. Brain Topogr. 31 (6), 985-1000.
• Gothe NP, Hayes JM, Temali C, Damoiseaux JS, 2018. Differences in Brain Structure and Function Among Yoga Practitioners and Controls. Frontiers in Integrative Neuroscience June 12-26.
• Hayes JM, Tang L, Viviano RP, van Rooden S, Ofen N, Damoiseaux JS, 2017. Subjective memory complaints are associated with brain activation supporting successful memory encoding. Neurobiol Aging 60, 71–80.
• Viviano RP, Raz N, Yuan P, Damoiseaux JS, 2017. Associations between dynamic functional connectivity and age, metabolic risk, and cognitive performance. Neurobiol Aging 59, 135–143.
• Damoiseaux JS, 2017. Effects of Aging on Functional and Structural Brain Connectivity. NeuroImage 160, 32–40.
• Damoiseaux JS, Huijbers W, 2016. The complementary value of task-evoked and resting-state functional imaging: a commentary on Campbell and Schacter (2016). Language, Cognition and Neuroscience Oct 25:1-3.
• Damoiseaux JS, Viviano RP, Yuan P, Raz N, 2016. Differential Effect of Age on Posterior and Anterior Hippocampal Functional Connectivity. NeuroImage 133, 468–476.
• White MP, Shirer WR, Molfino MJ, Tenison C, Damoiseaux JS, Greicius MD, 2013. Disordered reward processing and functional connectivity in trichotillomania: A pilot study. J Psychiatr Res. Sep;47(9):1264-72.
• Damoiseaux JS, Seeley WW, Zhou J, Shirer WR, Coppola G, Karydas A, Rosen HJ, Miller, BL, Kramer JH, Greicius MD, 2012. Gender Modulates the APOE ε4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels. J. NeuroSci. Jun 13;32(24):8254-8262.
• Damoiseaux JS, 2012. Resting-state fMRI as a biomarker for Alzheimer’s disease? Alzheimers Res Ther. Mar 15;4(3):8.
• Binnewijzend MA, Schoonheim MM, Sanz-Arigita E, Wink AM, van der Flier WM, Tolboom N, Adriaanse SM, Damoiseaux JS, Scheltens P, van Berckel BN, Barkhof F, 2012. Resting-state fMRI changes in Alzheimer’s disease and mild cognitive impairment. Neurobiol Aging Sep;33(9):2018-28.
• Damoiseaux JS, Prater K, Miller BL, Greicius MD, 2012. Functional connectivity tracks clinical deterioration in Alzheimer's disease. Neurobiol Aging Apr;33(4):828.e19-30.
• Sanz-Arigita EJ, Schoonheim MM, Damoiseaux JS, Rombouts SA, Maris E, Barkhof F, Scheltens P, Stam CJ, 2010. Loss of 'small-world' networks in Alzheimer's disease: graph analysis of FMRI resting-state functional connectivity. PLoS One Nov 1;5(11):e13788.
• Zarei M, Patenaude B, Damoiseaux J, Morgese C, Smith S, Matthews PM, Barkhof F, Rombouts S, Sanz-Arigita E, Jenkinson M, 2010. Combining shape and connectivity analysis: An MRI study of thalamic degeneration in Alzheimer's disease. Neuroimage Jan 1;49(1):1-8.
• Damoiseaux JS, Greicius MD, 2009. Greater Than the Sum of Its Parts: A Review of Studies Combining Structural Connectivity and Resting-State Functional Connectivity. Brain Struct Funct. Oct;213(6):525-33.
• Zarei M, Damoiseaux JS, Morgese C, Beckmann CF, Smith SM, Matthews PM, Scheltens P, Rombouts SA, Barkhof F, 2009. Regional White Matter Integrity Differentiates between Vascular Dementia and Alzheimer‘s Disease. Stroke Mar;40(3):773-9.
• Damoiseaux JS, Smith SM, Witter MP, Sanz-Arigita EJ, Barkhof F, Scheltens P, Stam CJ, Zarei M, Rombouts SA, 2009. White matter tract integrity in aging and Alzheimer's disease. Hum Brain Mapp. Apr;30(4):1051-9.
• Rombouts SA, Damoiseaux JS, Goekoop R, Barkhof F, Scheltens P, Smith SM, Beckmann CF, 2009. Model-free group analysis shows altered BOLD FMRI networks in dementia. Hum Brain Mapp. Jan;30(1):256-66.
• Damoiseaux JS, Beckmann CF, Sanz-Arigita EJ, Barkhof F, Scheltens P, Stam CJ, Smith SM, Rombouts SA, 2008. Reduced resting-state brain activity in the "default network" in normal aging. Cereb Cortex Aug;18(8):1856-64.
• Oei NY, Elzinga BM, Wolf OT, de Ruiter MB, Damoiseaux JS, Kuijer JP, Veltman DJ, Scheltens P, Rombouts SA, 2007. Glucocorticoids decrease hippocampal and prefrontal activation during declarative memory retrieval in young men. Brain Imaging Behav. Jun;1(1-2):31-41.
• Damoiseaux JS, Rombouts SA, Barkhof F, Scheltens P, Stam CJ, Smith SM, Beckmann CF, 2006. Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci U S A. Sep 12;103(37):13848-53.

Research Description

Dr. Damoiseaux's main research project is a longitudinal aging study, in which she collects neuroimaging data, genetics and neuropsychological data of healthy older adults. This study will allow her to investigate age-related changes in brain function and cognitive function, and the effect of biological and cognitive background on age-related changes within subjects.

Another project examines the differences in brain function between older adults with subjective cognitive impairment (SCI) and healthy older adults, and assesses the changes in brain function within these groups over time. The aim of this study is to examine whether SCI is a precursor of Alzheimer's disease (AD). SCI is a common condition in which a patient has memory complaints but no deficits on formal cognitive testing. Unlike amnestic mild cognitive impairment (MCI), which is widely recognized as a precursor of AD, it is still unclear whether SCI is a forerunner of AD, representing the latent phase of the disease.

Neuroimaging, Resting State fMRI, Functional Connectivity, Aging, Neurodegenerative Disease.

Affiliated Departments