Jessica Damoiseaux


Faculty Profile

Associate Professor




 87 East Ferry St., room 255 Knapp Building


Jessica Damoiseaux, Ph.D., is an Associate Professor in the Institute of Gerontology and the Department of Psychology. Dr. Damoiseaux' main research goal is to understand the changes in brain function and cognition that accompany normal and abnormal aging. She is particularly interested in examining the influence of biological and cognitive predisposition on cognitive and brain network connectivity changes in healthy older adults. The primary approach Dr. Damoiseaux uses to study brain network connectivity is functional magnetic resonance imaging (fMRI). In addition, she uses other neuroimaging techniques, such as structural MRI and diffusion imaging to study brain structure and structural brain connectivity.

Selected publications

Boots, A., Thomason, M. E., Espinoza-Heredia, C., Pruitt, P. J., Damoiseaux, J. S., Roseboom, T. J., & de Rooij, S. R. (2022). Sex-specific effects of prenatal undernutrition on resting-state functional connectivity in the human brain at age 68. Neurobiology of Aging, 112, 129–138.

Viviano, R. P., & Damoiseaux, J. S. (2021). Longitudinal change in hippocampal and dorsal anterior insulae functional connectivity in subjective cognitive decline. Alzheimer’s Research & Therapy, 13(1), 108.

Zhang, J., Kucyi, A., Raya, J., Nielsen, A. N., Nomi, J. S., Damoiseaux, J. S., Greene, D. J., Horovitz, S. G., Uddin, L. Q., & Whitfield-Gabrieli, S. (2021). What have we really learned from functional connectivity in clinical populations? NeuroImage, 242, 118466.

Ruiz-Rizzo, A., Pruitt, P., Finke, K., Müller, H., & Damoiseaux, J. (2021). Lower-Resolution Retrieval of Scenes in Older Adults With Subjective Cognitive Decline. Archives of Clinical Neuropsychology.

Jung, Y., Viviano, R. P., van Rooden, S., van der Grond, J., Rombouts, S. A. R. B., & Damoiseaux, J. S. (2021). White Matter Hyperintensities and Apolipoprotein E Affect the Association Between Mean Arterial Pressure and Objective and Subjective Cognitive Functioning in Older Adults. Journal of Alzheimer’s Disease, 84(3), 1337–1350.

Viviano RP, Damoiseaux JS (2020). Functional Neuroimaging in Subjective Cognitive Decline: Current Status and a Research Path Forward. Alzheimer's Research & Therapy 12 (1), 1-18.

Gothe NP, Kahn I, Hayes JM, Erlenbach E, Damoiseaux JS, 2019. Yoga Effects on Brain Health: A Systematic Review of the Current Literature. Brain Plasticity 5, 105-122.

Viviano RP, Hayes JM, Pruitt PJ, Fernandez Z, van Rooden S, van der Grond J, Rombouts SA, Damoiseaux JS, 2019. Aberrant memory system connectivity and working memory performance in subjective cognitive decline. NeuroImage185, 556-564.

van Rooden S, van den Berg-Huysmans AA, Croll PH, Labadie G, Hayes JM, Viviano RP, van der Grond J, Rombouts SA, Damoiseaux JS, 2018. Subjective cognitive decline is associated with greater white matter hyperintensity volume. J Alzheimers Dis. 1-12.

Damoiseaux JS, Viviano RP, Yuan P, Raz N, 2016. Differential Effect of Age on Posterior and Anterior Hippocampal Functional Connectivity. NeuroImage 133, 468–476.

Damoiseaux JS, Prater K, Miller BL, Greicius MD, 2012. Functional connectivity tracks clinical deterioration in Alzheimer's disease. Neurobiol Aging Apr;33(4):828.e19-30.

Damoiseaux JS, Beckmann CF, Sanz-Arigita EJ, Barkhof F, Scheltens P, Stam CJ, Smith SM, Rombouts SA, 2008. Reduced resting-state brain activity in the "default network" in normal aging. Cereb Cortex Aug;18(8):1856-64.

Damoiseaux JS, Rombouts SA, Barkhof F, Scheltens P, Stam CJ, Smith SM, Beckmann CF, 2006. Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci U S A. Sep 12;103(37):13848-53.


Research Description

Dr. Damoiseaux's main research project is a longitudinal aging study, in which she collects neuroimaging data, genetics and neuropsychological data of healthy older adults. This study will allow her to investigate age-related changes in brain function and cognitive function, and the effect of biological and cognitive background on age-related changes within subjects.

Another project examines the differences in brain function between older adults with subjective cognitive impairment (SCI) and healthy older adults, and assesses the changes in brain function within these groups over time. The aim of this study is to examine whether SCI is a precursor of Alzheimer's disease (AD). SCI is a common condition in which a patient has memory complaints but no deficits on formal cognitive testing. Unlike amnestic mild cognitive impairment (MCI), which is widely recognized as a precursor of AD, it is still unclear whether SCI is a forerunner of AD, representing the latent phase of the disease.

Neuroimaging, Resting State fMRI, Functional Connectivity, Aging, Neurodegenerative Disease.

Affiliated Departments