Susanne Brummelte

Faculty Profile

Assistant Professor
ff6300@wayne.edu

Phone

313-577-2834

Fax

313-577-7636

Office

 Room 8307.3 5057 Woodward Avenue

Selected Publications

 Link to all publications: Pubmed

  • Brummelte S, Mc Glanaghy E, Bonnin A, Oberlander TF (2017): Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation. Neuroscience 342: 212-231
  • Mooney-Leber SM*, Brummelte S (2017): Neonatal pain and reduced maternal care: early life stressors interacting to impact brain and behavioral development of preterm infants. Neuroscience 342:21-36
  • Kott JM, Mooney-Leber SM, Shoubah FA, Brummelte S. (2016): Effectiveness of different corticosterone administration methods to elevate corticosterone serum levels, induce depressive-like behavior and affect neurogenesis levels in female rats. Neuroscience 312:201-14
  • Brummelte S and Galea LAM (2016):. Postpartum depression: etiology, treatment and consequences for maternal care. Hormones and Behavior 77:153-66.
  • Brummelte S, Chau CMY, Cepeda IL, Degenhardt A, Weinberg J, Synnes AR, Grunau RE (2015): Cortisol levels in former preterm children at school age are predicted by neonatal procedural pain-related stress. Psychoneuroendocrinology 51C:151-163
  • Grunau RE, Cepeda IL, Chau CMY, Brummelte S, Weinberg J, Lavoie P, Ladd M, Hirschfeld AF, Russel E, Koren G, Van Uum S, Brant R, Turvey SE (2013): Neonatal pain-related stress and NFKBIA genotype are associated with altered cortisol levels in preterm boys at school age. PLoS One 16;8(9):e73926
  • Brummelte S, Galea LAM, Devlin AM and Oberlander TF (2013): Antidepressant Use during Pregnancy and Serotonin Transporter Genotype (SLC6A4) Affect Newborn Serum Reelin Levels. Dev. Psychobiol. 55(5):518-29
  • Brummelte S, Grunau RE, Chau V, Poskitt KJ, Vinall J, Gover A, Synnes AR and Miller SP (2012): Procedural pain and brain development in premature newborns. Annals of Neurology 71(3):385-96
  • Brummelte S, Lieblich SE and Galea LAM (2012): Gestational and postpartum corticosterone exposure to the dam affects behavioral and neuroendocrine outcome of the offspring. Neuropharmacology 62(1):406-18
  • Wong JHK, Brummelte S and Galea LAM (2011): Elevated corticosterone levels during the first postpartum period influences subsequent pregnancy outcome and behaviour of the dam. J Neuroendocrinol 23(11):1156-65
  • Brummelte S, Grunau RE, Zaidman-Zait A, Weinberg J, Nordstokke D and Cepeda I (2011): Cortisol levels in relation to maternal interaction and child internalizing behavior in preterm and full term children at 18 months corrected age. Dev Psychobiol 53(2):184-95
  • Brummelte S and Galea LAM (2010): Depression during pregnancy and postpartum: contribution of stress and ovarian hormones. Prog Neuropsychopharmacol Biol Psychiatry 34(5):766-76
  • Brummelte S and Galea LAM (2010): Effects of chronic corticosterone during pregnancy and the postpartum period on maternal care, behavioural and neuronal markers of depression in the dam. Horm Behav 58(5):769-79
  • Brummelte S and Galea LAM (2010): Chronic corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats. Neuroscience 168(3):680-90
  • Brummelte S, Neddens J, and Teuchert-Noodt G (2007): Alteration in the GABAergic network of the prefrontal cortex in an animal model of psychosis. J Neural Trans 114(5):539-47
  • Brummelte S, Pawluski JL and Galea LAM (2006): High postpartum levels of corticosterone given to dams influence postnatal hippocampal cell proliferation and behaviour of offspring: A model of post-partum stress and possible depression. Horm Behav 50(3):370-82

Book Chapters

  • Barha CK, Barker JM, Brummelte S, Epp JR and Galea LAM: Hormone Regulation of Adult Hippocampal Neurogenesis in the Mammalian Brain. In. D. Pfaff et al. (Ed.). Hormones, Brain and Behavior, Edition 2. Academic Press/Elsevier 2009, San Diego, CA. ISBN 0123743826 / 9780123743824
  • Crozier TM, Pawluski JL, Brummelte S and Galea LAM: The Contribution of Reproductive Experience. Gonadal and Peptide hormones on Dendritic Spine Density and Morphology: Possible contribution to function. In F. Columbus (Ed.), Dendritic Spines: Biochemistry, Modeling and Properties. Nova Science Publishers Inc. 2010, Hauppauge, NY. ISBN 978-1-60741-460-5
  • Brummelte S, Craig KD and Oberlander TF: Physiological Indices of Pain Reactivity in Infants and Children. In McGrath et al (Ed.): The Oxford Textbook of Pediatric Pain, Oxford University Press,2013, Oxford, UK. ISBN 978-0-19-964265-6
  • Duarte-Guterman, P., Yagi, S., Epp, J.R., Brummelte, S., Wainwright, S.R., Barha, C.K., Chow, C., Barker, J.M., Galea, L.A.M. Hormone Regulation of Neurogenesis Across the Lifespan. In: Pfaff, D.W and Joëls, M. (Ed.). Hormones, Brain, and Behavior, 3rd edition, Vol 5. Oxford: Academic Press; 2017. pp. 373–410.
     

 

Courses taught

 Undergraduate
• PSY3120 Brain and Behavior, 3 credits, Winter 2013-Winter 2016
• PSY2080 Intr. to Drugs, Behavior and Society, 3 credits, Winter 2013, Fall 2013, Winter 2014, Fall 2016


Graduate
• PSY7120 Biological Basis of Behavior, 3 credits, Winter 2015, Winter 2016
• PSY7991 Current Topics in Behavioral Neuroscience, 1 credit, Fall 2014-Fall 2016

 

Research Description

Our current research focuses on the effects of early adverse life experience on brain development and the subsequent behavioral and neuroanatomical changes in both males and females. We are particularly interested in the consequences of exposure to depression, stress, or glucocorticoids during pregnancy or the postpartum period and how this affects brain neurochemistry and stress responsivity later in life. Further, my lab studies the effects of early pain exposure as well as medications such as anti- depressants on brain development using rats as the animal model of choice. The research will address important questions on how exposure to early adverse conditions such as pharmacological treatments can influence the maturation of the nervous system and the long-term outcome of the offspring.
Potential projects for students in the lab include slicing rat brains, helping with immunohistochemistry (i.e. staining brain slices) and protein assays, counting brain cells and helping with animal observations and behavioral testing. We usually expect students to commit at least 10hr per week (or more) and to be willing to work in the lab for at least a year (as it takes some time to get trained), preferably more.

Affiliated Departments

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