Weilong Hao

projects

Faculty Profile

Associate Professor
ex8688@wayne.edu

Department

Biological Sciences

Phone

313-577-6450

Fax

313-577-6891

Office

BSB 5107.1

Selected Publications

Hao group members are in bold face.

  • Undergraduate students are underlined
  • Corresponding author*
  • Equal contribution# 

2022

(42) Wu B*, Hao W, Cox MP* (2022) Reconstruction of gene innovation associated with major evolutionary transitions in the kingdom Fungi. BMC Biology [Pubmed] [Reprint]

(41) Hao W* (2022) From genome variation to molecular mechanisms: what we have learned from yeast mitochondrial genomes? Frontiers in Microbiology [Pubmed] [Reprint]

2020

(40) Nguyen DT, Wu B, Xiao S, Hao W* (2020) Evolution of a record-setting AT-rich genome: indel mutation, recombination, and substitution bias. Genome Biology and Evolution 12:2344-2354. [Pubmed] [Reprint]

(39) Nguyen DT, Wu B, Long H*, Zhang N, Patterson C, Simpson S, Morris K, Thomas WK, Lynch M, Hao W* (2020) Variable spontaneous mutation and loss of heterozygosity among heterozygous genomes in yeast. Molecular Biology and Evolution 37:3118-3130. [Pubmed] [Reprint]

(38) Plazyo O, Hao W*, Jin JP* (2020) The absence of Calponin 2 in rabbit suggests caution in choice of animal model. Frontiers in Bioengineering and Biotechnology 8:42. [Pubmed] [Reprint]

2019

(37) Wu B, Hao W* (2019) Mitochondrial-encoded endonucleases drive recombination of protein coding genes in yeast. Environmental Microbiology 21:4233-4240. [Pubmed] [Reprint]

(36) Su HJ, Barkman TJ, Hao W, Jones SS, Naumann J, Skippington E, Wafula EK, Hu JM, Palmer JD, dePamphilis CW* (2019) A novel genetic code and record-setting AT-richness in the highly reduced plastid genome of the holoparasitic plant Balanophora. Proc Natl Acad Sci U S A 116: 934-943. [Pubmed] [Reprint]

2018

(35) Mafiz A, Perera LN, He Y, Zhang W, Xiao S, Hao W, Sun S, Zhou K, Zhang Y* (2018) A case study on soil antibiotic resistome in an urban community garden. International Journal of Antimicrobial Agents 52:241-250. [Pubmed] [Reprint]

2017

(34) Xiao S#, Nguyen DT#, Wu B, Hao W* (2017) Genetic drift and indel mutation in the evolution of yeast mitochondrial genome size. Genome Biology and Evolution 9:3088-3099. [Pubmed] [Reprint]

(33) Wu B, Macielog AI, Hao W* (2017) Origin and spread of spliceosomal introns: insights from the fungal clade Zymoseptoria. Genome Biology and Evolution 9:2658-2667. [Pubmed] [Reprint]

2016

(32) Ha SW, Ju D, Hao W, Xie Y* (2016) Rapidly translated polypeptides are preferred substrates for cotranslational protein degradation. Journal of Biological Chemistry 291:9827-9834. [Pubmed] [Reprint]

(31) Bhagwat AS*, Hao W, Townes JP, Lee H, Tang H, Foster PL (2016) Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli. Proc Natl Acad Sci U S A 113:2176-2181. [Pubmed] [Reprint]

2015

(30) Wu B, Buljic A, Hao W* (2015) Extensive horizontal transfer and homologous recombination generate highly chimeric mitochondrial genomes in yeast. Molecular Biology and Evolution 32:2559-2570. [Pubmed] [Reprint]

(29) Wu B, Hao W* (2015) A dynamic mobile DNA family in the yeast mitochondrial genome. G3: Genes | Genomes | Genetics 5:1273-1282. [Pubmed] [Reprint]

2014

(28) Kim T, Hao W* (2014) DiscML: an R package for estimating evolutionary rates of discrete characters using maximum likelihood. BMC Bioinformatics 15: 320. [Pubmed] [Reprint]

(27) Wu B, Hao W* (2014) Horizontal transfer and gene conversion as an important driving force in shaping the landscape of mitochondrial intron. G3: Genes | Genomes | Genetics 4:605-612. [Pubmed] [Reprint]

2013

(26) Kong Y, Ma JH, Warren K, Tsang RS, Low DE, Jamieson FB, Alexander DC, Hao W* (2013) Homologous recombination drives both sequence diversity and gene content variation in Neisseria meningitidis. Genome Biology and Evolution 5:1611-1627. [Pubmed] [Reprint]

(25) Hao W* (2013) Unrecognized fine-scale recombination can mimic the effects of adaptive radiation. Gene 518:483-488. [Pubmed] [Reprint]

(24) Hao W* (2013) Extensive genomic variation within clonal bacterial groups resulted from homologous recombination. Mobile Genetic Elements 3:e23463. [Pubmed] [Reprint]

2012

(23) Hao W* Allen VG, Jamieson FB, Low DE and Alexander DC (2012) Phylogenetic incongruence in E. coli O104: Understanding the evolutionary relationships of emerging pathogens in the face of homologous recombination. PLoS One 7: e33971. [Pubmed] [Reprint] [Supplementary Data]

(22) Hao W* (2012) Fast rates of evolution in bacteria due to horizontal gene transfer, in Rapidly Evolving Genes and Genetic Systems, Oxford University Press, (Book Chapter) [Publisher's website]

(21) Alexander DC, Hao W, Gilmour M, Zittermann S, Sarabia A, Melano R, Peralta A, Lombos M, Warren K, Amatnieks Y, Virey E, Ma JH, Jamieson FB, Low DE and Allen VG (2012) Escherichia coli O104:H4 infections associated with international travel. Emerging Infectious Diseases 18:473-476. [Pubmed] [Reprint]

2011

(20) Hao W and Palmer JD (2011) HGT turbulence: Confounding phylogenetic influence of duplicative horizontal transfer and differential gene conversion. Mobile Genetic Elements 1:256-261. [Pubmed] [Reprint]

(19) Hao W, Ma JH, Warren K, Tsang RS, Low DE, Jamieson FB and Alexander DC (2011) Extensive genomic variation within clonal complexes of Neisseria meningitidis. Genome Biology and Evolution 3:1406-1418. [Pubmed] [Reprint] [Supplementary Data]

(18) Hao W. (2011) Evidence of Intra-segmental homologous recombination in Influenza A virus. Gene 481:57-64. [Pubmed] [Reprint]

2010

(17) Mower JP, Stefanovic S, Hao W, Gummow JS, Jain K, Ahmed D and Palmer JD (2010) Horizontal acquisition of multiple mitochondrial genes from a parasitic plant followed by gene conversion with host mitochondrial genes. BMC Biology 8: 150. [Pubmed] [Reprint] [Commentary by Archibald and Richards] (16) Hao W#, Richardson AO#, Zheng Y and Palmer JD (2010) Gorgeous mosaic of mitochondrial genes created by horizontal transfer and gene conversion. Proc Natl Acad Sci U S A 107: 21576-21581. [Pubmed] [Reprint] [Commentary by Archibald and Richards]

(15) Hao W and Golding GB (2010) Inferring bacterial genome flux while considering truncated genes. Genetics 186: 411-426. [Pubmed]

(14) Hao W (2010) OrgConv: detection of gene conversion using consensus sequences and its application in plant mitochondrial and chloroplast homologs. BMC Bioinformatics 11: 114. [Pubmed] [Reprint]

(13) Hao W and Golding GB (2010) Pattern of horizontal gene transfer in bacteria, in Microbial Population Genetics, Horizon Scientific Press. (book chapter) [Publisher's website]

2009

(12) Hao W and Palmer JD (2009) Fine-scale mergers of chloroplast and mitochondrial genes create functional, transcompartmentally chimeric mitochondrial genes. Proc Natl Acad Sci U S A 106: 16728-16733. [Pubmed] [Reprint] (11) Hao W and Golding GB (2009) Does gene translocation accelerate the evolution of laterally transferred genes? Genetics 182:1365-1375. [Pubmed] [Reprint]

2008

(10) Hao W and Golding GB (2008) High rates of lateral gene transfer are not due to false diagnosis of gene absence. Gene 421:27-31. [Pubmed]

(9) Hao W and Golding GB (2008) Uncovering rate variation of lateral gene transfer during bacterial genome evolution. BMC Genomics 9: 235. [Pubmed] [Reprint]

2007

(8) Higgs PG, Hao W and Golding GB (2007) Identification of conflicting selective effects on highly expressed genes. Evolutionary Bioinformatics 2: 1-13. [Pubmed] [Reprint]

(7) Marri PR#, Hao W# and Golding GB (2007) The role of laterally transferred genes in adaptive evolution. BMC Evolutionary Biology 7(Suppl 1):S8 (14 pages). [Pubmed]

2006

(6) Hao W and Golding GB (2006) The fate of laterally transferred genes: Life in the fast lane to adaptation or death. Genome Research 16:636-643. [Pubmed] [Reprint] [Highlighted by I. King Jordan]

(5) Marri PR#, Hao W# and Golding GB (2006) Gene gain and gene loss in Streptococcus: Is it driven by habitat? Molecular Biology and Evolution 23: 2379-2391. [Pubmed] [Reprint]

(4) Hao W and Golding GB (2006) Asymmetrical evolution of Cytochrome bd subunits. Journal of Molecular Evolution 62: 132-142. [Pubmed]

2005

(3) Lee YK, Hao W, Ho PS, Nordling MM, Low CS, Kok TM and Rafter J (2005) Human fecal water modifies adhesion of intestinal bacteria to caco-2 cells. Nutrition and Cancer 52: 35-42. [Pubmed]

2004

(2) Hao W and Golding GB (2004) Patterns of bacterial gene movement. Molecular Biology and Evolution 21: 1294-1307. [Pubmed] [Reprint]

(1) Hao W and Lee YK (2004) Microflora of the gastrointestinal tract: A Review, in Public Health Microbiology: Methods and Protocols (Methods in Molecular Biology), pps. 491-502 Humana Press, Totowa, NJ. (book chapter) [Pubmed]

2022

(42) Wu B*, Hao W, Cox MP* (2022) Reconstruction of gene innovation associated with major evolutionary transitions in the kingdom Fungi. BMC Biology [Pubmed] [Reprint]

(41) Hao W* (2022) From genome variation to molecular mechanisms: what we have learned from yeast mitochondrial genomes? Frontiers in Microbiology [Pubmed] [Reprint]

2020

(40) Nguyen DT, Wu B, Xiao S, Hao W* (2020) Evolution of a record-setting AT-rich genome: indel mutation, recombination, and substitution bias. Genome Biology and Evolution 12:2344-2354. [Pubmed] [Reprint]

(39) Nguyen DT, Wu B, Long H*, Zhang N, Patterson C, Simpson S, Morris K, Thomas WK, Lynch M, Hao W* (2020) Variable spontaneous mutation and loss of heterozygosity among heterozygous genomes in yeast. Molecular Biology and Evolution 37:3118-3130. [Pubmed] [Reprint]

(38) Plazyo O, Hao W*, Jin JP* (2020) The absence of Calponin 2 in rabbit suggests caution in choice of animal model. Frontiers in Bioengineering and Biotechnology 8:42. [Pubmed] [Reprint]

2019

(37) Wu B, Hao W* (2019) Mitochondrial-encoded endonucleases drive recombination of protein coding genes in yeast. Environmental Microbiology 21:4233-4240. [Pubmed] [Reprint]

(36) Su HJ, Barkman TJ, Hao W, Jones SS, Naumann J, Skippington E, Wafula EK, Hu JM, Palmer JD, dePamphilis CW* (2019) A novel genetic code and record-setting AT-richness in the highly reduced plastid genome of the holoparasitic plant Balanophora. Proc Natl Acad Sci U S A 116: 934-943. [Pubmed] [Reprint]

2018

(35) Mafiz A, Perera LN, He Y, Zhang W, Xiao S, Hao W, Sun S, Zhou K, Zhang Y* (2018) A case study on soil antibiotic resistome in an urban community garden. International Journal of Antimicrobial Agents 52:241-250. [Pubmed] [Reprint]

2017

(34) Xiao S#, Nguyen DT#, Wu B, Hao W* (2017) Genetic drift and indel mutation in the evolution of yeast mitochondrial genome size. Genome Biology and Evolution 9:3088-3099. [Pubmed] [Reprint]

(33) Wu B, Macielog AI, Hao W* (2017) Origin and spread of spliceosomal introns: insights from the fungal clade Zymoseptoria. Genome Biology and Evolution 9:2658-2667. [Pubmed] [Reprint]

2016

(32) Ha SW, Ju D, Hao W, Xie Y* (2016) Rapidly translated polypeptides are preferred substrates for cotranslational protein degradation. Journal of Biological Chemistry 291:9827-9834. [Pubmed] [Reprint]

(31) Bhagwat AS*, Hao W, Townes JP, Lee H, Tang H, Foster PL (2016) Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli. Proc Natl Acad Sci U S A 113:2176-2181. [Pubmed] [Reprint]

2015

(30) Wu B, Buljic A, Hao W* (2015) Extensive horizontal transfer and homologous recombination generate highly chimeric mitochondrial genomes in yeast. Molecular Biology and Evolution 32:2559-2570. [Pubmed] [Reprint]

(29) Wu B, Hao W* (2015) A dynamic mobile DNA family in the yeast mitochondrial genome. G3: Genes | Genomes | Genetics 5:1273-1282. [Pubmed] [Reprint]

2014

(28) Kim T, Hao W* (2014) DiscML: an R package for estimating evolutionary rates of discrete characters using maximum likelihood. BMC Bioinformatics 15: 320. [Pubmed] [Reprint]

(27) Wu B, Hao W* (2014) Horizontal transfer and gene conversion as an important driving force in shaping the landscape of mitochondrial intron. G3: Genes | Genomes | Genetics 4:605-612. [Pubmed] [Reprint]

2013

(26) Kong Y, Ma JH, Warren K, Tsang RS, Low DE, Jamieson FB, Alexander DC, Hao W* (2013) Homologous recombination drives both sequence diversity and gene content variation in Neisseria meningitidis. Genome Biology and Evolution 5:1611-1627. [Pubmed] [Reprint]

(25) Hao W* (2013) Unrecognized fine-scale recombination can mimic the effects of adaptive radiation. Gene 518:483-488. [Pubmed] [Reprint]

(24) Hao W* (2013) Extensive genomic variation within clonal bacterial groups resulted from homologous recombination. Mobile Genetic Elements 3:e23463. [Pubmed] [Reprint]

2012

(23) Hao W* Allen VG, Jamieson FB, Low DE and Alexander DC (2012) Phylogenetic incongruence in E. coli O104: Understanding the evolutionary relationships of emerging pathogens in the face of homologous recombination. PLoS One 7: e33971. [Pubmed] [Reprint] [Supplementary Data]

(22) Hao W* (2012) Fast rates of evolution in bacteria due to horizontal gene transfer, in Rapidly Evolving Genes and Genetic Systems, Oxford University Press, (Book Chapter) [Publisher's website]

(21) Alexander DC, Hao W, Gilmour M, Zittermann S, Sarabia A, Melano R, Peralta A, Lombos M, Warren K, Amatnieks Y, Virey E, Ma JH, Jamieson FB, Low DE and Allen VG (2012) Escherichia coli O104:H4 infections associated with international travel. Emerging Infectious Diseases 18:473-476. [Pubmed] [Reprint]

2011

(20) Hao W and Palmer JD (2011) HGT turbulence: Confounding phylogenetic influence of duplicative horizontal transfer and differential gene conversion. Mobile Genetic Elements 1:256-261. [Pubmed] [Reprint]

(19) Hao W, Ma JH, Warren K, Tsang RS, Low DE, Jamieson FB and Alexander DC (2011) Extensive genomic variation within clonal complexes of Neisseria meningitidis. Genome Biology and Evolution 3:1406-1418. [Pubmed] [Reprint] [Supplementary Data]

(18) Hao W. (2011) Evidence of Intra-segmental homologous recombination in Influenza A virus. Gene 481:57-64. [Pubmed] [Reprint]

2010

(17) Mower JP, Stefanovic S, Hao W, Gummow JS, Jain K, Ahmed D and Palmer JD (2010) Horizontal acquisition of multiple mitochondrial genes from a parasitic plant followed by gene conversion with host mitochondrial genes. BMC Biology 8: 150. [Pubmed] [Reprint] [Commentary by Archibald and Richards] (16) Hao W#, Richardson AO#, Zheng Y and Palmer JD (2010) Gorgeous mosaic of mitochondrial genes created by horizontal transfer and gene conversion. Proc Natl Acad Sci U S A 107: 21576-21581. [Pubmed] [Reprint] [Commentary by Archibald and Richards]

(15) Hao W and Golding GB (2010) Inferring bacterial genome flux while considering truncated genes. Genetics 186: 411-426. [Pubmed] [Reprint]

(14) Hao W (2010) OrgConv: detection of gene conversion using consensus sequences and its application in plant mitochondrial and chloroplast homologs. BMC Bioinformatics 11: 114. [Pubmed] [Reprint]

(13) Hao W and Golding GB (2010) Pattern of horizontal gene transfer in bacteria, in Microbial Population Genetics, Horizon Scientific Press. (book chapter) [Publisher's website]

2009

(12) Hao W and Palmer JD (2009) Fine-scale mergers of chloroplast and mitochondrial genes create functional, transcompartmentally chimeric mitochondrial genes. Proc Natl Acad Sci U S A 106: 16728-16733. [Pubmed] [Reprint]

(11) Hao W and Golding GB (2009) Does gene translocation accelerate the evolution of laterally transferred genes? Genetics 182:1365-1375. [Pubmed] [Reprint]

2008

(10) Hao W and Golding GB (2008) High rates of lateral gene transfer are not due to false diagnosis of gene absence. Gene 421:27-31. [Pubmed]

(9) Hao W and Golding GB (2008) Uncovering rate variation of lateral gene transfer during bacterial genome evolution. BMC Genomics 9: 235. [Pubmed] [Reprint]

2007

(8) Higgs PG, Hao W and Golding GB (2007) Identification of conflicting selective effects on highly expressed genes. Evolutionary Bioinformatics 2: 1-13. [Pubmed] [Reprint]

(7) Marri PR#, Hao W# and Golding GB (2007) The role of laterally transferred genes in adaptive evolution. BMC Evolutionary Biology 7(Suppl 1):S8 (14 pages). [Pubmed]

2006

(6) Hao W and Golding GB (2006) The fate of laterally transferred genes: Life in the fast lane to adaptation or death. Genome Research 16:636-643. [Pubmed] [Reprint] [Highlighted by I. King Jordan]

(5) Marri PR#, Hao W# and Golding GB (2006) Gene gain and gene loss in Streptococcus: Is it driven by habitat? Molecular Biology and Evolution 23: 2379-2391. [Pubmed] [Reprint]

(4) Hao W and Golding GB (2006) Asymmetrical evolution of Cytochrome bd subunits. Journal of Molecular Evolution 62: 132-142. [Pubmed]

2005

(3) Lee YK, Hao W, Ho PS, Nordling MM, Low CS, Kok TM and Rafter J (2005) Human fecal water modifies adhesion of intestinal bacteria to caco-2 cells. Nutrition and Cancer 52: 35-42. [Pubmed]

2004

(2) Hao W and Golding GB (2004) Patterns of bacterial gene movement. Molecular Biology and Evolution 21: 1294-1307. [Pubmed] [Reprint]

(1) Hao W and Lee YK (2004) Microflora of the gastrointestinal tract: A Review, in Public Health Microbiology: Methods and Protocols (Methods in Molecular Biology), pps. 491-502 Humana Press, Totowa, NJ. (book chapter) [Pubmed]

Courses taught

  • BIO1500 (BUILD)
  • BIO1510 (BUILD)
  • BIO4200 (2013-2020)
  • BIO6994 (2020)

Research Description

We employ genomic tools to understand the evolution and epidemiology of bacterial pathogens, the frequency of mitochondrial recombination and its effects on fitness and aging in eukaryotes.

Affiliated Departments

Tags