Young Hoon Ahn

Faculty Profile

Associate Professor
fb7480@wayne.edu

Department

Chemistry

Phone

313-577-1384

Fax

313-577-8822

Office

Chem 421

Selected Publications

Gurusingha Arachchige, H. S., Herath Mudiyanselage, P. D. H., VanHeck, G. C., Patel, K., Cheaito, H. A., Dou, Q. P., Ahn, Y. H. Synthesis and Evaluation of Tiaprofenic Acid-derived UCHL5 Deubiquitinase Inhibitors, Bioorg. Med. Chem. 2020, In press.

VanHecke, G. C.,ª Yapa Abeywardana, M.,ª Huang, B., Ahn, Y. H. Isotopically-labelled Clickable Glutathione to Quantify Protein S-Glutathionylation, ChemBioChem, 2020, 21, 853-859. ª equal contribution

VanHecke, G. C., Yapa Abeywardana, M., Ahn, Y. H. Proteomic Identification of Protein Glutathionylation in Cardiomyocytes, J. Proteome Res. 2019, 18, 1806-1818.

Munkanatta Godage, D. N. P., VanHecke, G. C., Samarasinghe, K. T. G., Feng, H. Z., Hiske, M., Holcomb, J., Yang, Z., Jin, J. -P., Chung, C. S., Ahn, Y. H. SMYD2 Glutathionylation Contributes to Degradation of Sarcomeric Proteins. Nature Commun. 2018, 9, 4341

Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., Zhou, Y., Ndombera, F. T., Weerapana, E., Ahn, Y. H.* Clickable Glutathione Approach for Identification of Protein Glutathionylation in Response to Glucose Metabolism. Mol. Biosyst. 2016, 12, 2471-2480.

Ndombera, F. T., VanHecke, G. C., Nagi, S., Ahn, Y. H.* Carbohydrate-based Inducers of Cellular Stress for Targeting Cancer Cells. Bioorg. Med. Chem. Lett. 201626, 1452-1456.

Samarasinghe, K. T. G., Ahn, Y. H.* Synthesizing Clickable Glutathione by Glutathione Synthetase Mutant for Detecting Protein Glutathionylation. SynLett. 201526, 285-293.

Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., VanHecke, G. C., Ahn, Y. H.* Metabolic Synthesis of Clickable Glutathione for Chemoselective Detection of Glutathionylation. J. Am. Chem. Soc. 2014136, 11566-11569.

Courses taught

CHM 1030 Survey of Organic and Bioorganic Chemsitry

CHM 5600 Survey: Biochemistry

CHM 6270 Advanced Bioorganic Chemistry and Drug Design

CHM 6620 Metabolism: Pathway and Regulation: Biochemistry

CHM 6610 Biological Chemistry Laboratory

CHM 7600 Structure & Function: Biomolecules

CHM 7620 Metabolism: Pathway and Regulation: Biochemistry

Research Description

Chemical biology for understanding protein Cys modification in oxidative stress and cytoprotection

Affiliated Departments